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CAS 367-21-5
3-chloro-4-fluoroaniline
Codes: AFAT-004, GEFT-010
Application context (from source-drug indications)
Non-small cell lung cancerAfatinib DimaleateHead and neck squamous cell carcinomaAfatinib DimaleateHead and neck cancerAfatinib DimaleateChordomaAfatinib DimaleateSquamous cell carcinomaAfatinib DimaleateGallbladder cancerAfatinib DimaleateNon-small cell lung cancerGefitinibLung cancerGefitinibHead and neck cancerGefitinibBreast cancerGefitinib唇肿瘤Gefitinib喉肿瘤Gefitinib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Afatinib Dimaleate | Tier C — Watch / trade | - |
| Gefitinib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-amino-4-fluoro-5-nitrobenzoic acid→N-(4-((3-chloro-4-fluorophenyl)(3,4-dimethoxybenzyl)amino)-7-(3-morpholinopropoxy)quinazolin-6-yl)acrylamide→3-chloro-N-(3,4-dimethoxybenzyl)-4-fluoroaniline→3-chloro-4-fluoroaniline→N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine→(S)-tetrahydrofuran-3-ol→(S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine→(S)-N4-(3-chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine→(E)-4-bromobut-2-enoic acid
3-chloro-4-fluoroaniline→(S)-tetrahydrofuran-3-ol→(S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine→(S)-N4-(3-chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine→2-amino-4-chlorobenzoic acid→7-chloroquinazolin-4(3H)-one→7-chloro-6-nitroquinazolin-4(4aH)-one→4,7-dichloro-6-nitroquinazoline→N-(3-chloro-4-fluorophenyl)-6-nitro-7-(phenylsulfonyl)quinazolin-4-amine→2-(diethoxyphosphoryl)acetic acid→(S)-diethyl (2-((4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)-2-oxoethyl)phosphonate→2,2-diethoxy-N,N-dimethylethanamine→maleic acid
3-chloro-4-fluoroaniline→(S)-tetrahydrofuran-3-ol→methyl 3-amino-4-hydroxybenzoate→methyl 5-amino-4-hydroxy-2-nitrobenzoate→methyl 2,5-diamino-4-hydroxybenzoate→6-amino-7-hydroxyquinazolin-4(3H)-one→6-amino-4-chloroquinazolin-7-ol→(S)-4-chloro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-amine→(E)-4-(dimethylamino)but-2-enoyl chloride→(S,E)-N-(4-chloro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
3-chloro-4-fluoroaniline→(S)-tetrahydrofuran-3-ol→(E)-4-(dimethylamino)but-2-enoyl chloride→4-hydroxybenzonitrile→4-hydroxy-3-nitrobenzonitrile→(S)-3-nitro-4-((tetrahydrofuran-3-yl)oxy)benzonitrile→(S)-3-amino-4-((tetrahydrofuran-3-yl)oxy)benzonitrile→(S,E)-N-(5-cyano-2-((tetrahydrofuran-3-yl)oxy)phenyl)-4-(dimethylamino)but-2-enamide→(S,E)-N-(5-cyano-4-nitro-2-((tetrahydrofuran-3-yl)oxy)phenyl)-4-(dimethylamino)but-2-enamide→(S,E)-N-(4-amino-5-cyano-2-((tetrahydrofuran-3-yl)oxy)phenyl)-4-(dimethylamino)but-2-enamide→(E)-N-(5-cyano-4-((E)-((dimethylamino)methylene)amino)-2-(((S)-tetrahydrofuran-3-yl)oxy)phenyl)-4-(dimethylamino)but-2-enamide
3-hydroxy-4-methoxybenzaldehyde→3-hydroxy-4-methoxybenzonitrile→4-(3-chloropropyl)morpholine→4-methoxy-3-(3-morpholinopropoxy)benzonitrile→4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile→2-amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile→2-amino-4-methoxy-5-(3-morpholinopropoxy)benzamide→7-methoxy-6-(3-morpholinopropoxy)quinazolin-4(1H)-one→4-(3-((4-chloro-7-methoxyquinazolin-6-yl)oxy)propyl)morpholine→3-chloro-4-fluoroaniline
4-(3-chloropropyl)morpholine→3-chloro-4-fluoroaniline→6,7-dimethoxyquinazolin-4(3H)-one→L-methionine→6-hydroxy-7-methoxyquinazolin-4(3H)-one→7-methoxy-4-oxo-3,4-dihydroquinazolin-6-yl acetate→4-chloro-7-methoxyquinazolin-6-yl acetate hydrochloride→4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate→4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-ol
3-hydroxy-4-methoxybenzaldehyde→3-hydroxy-4-methoxybenzonitrile→4-(3-chloropropyl)morpholine→4-methoxy-3-(3-morpholinopropoxy)benzonitrile→4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile→2-amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile→3-chloro-4-fluoroaniline→(E)-N,N'-bis(3-chloro-4-fluorophenyl)formimidamide
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