CAS 368890-20-4

2-[[(4-Chloro-3-methoxypyridin-2-yl)methyl]sulfanyl]-5-(difluoromethoxy)-1H-benzimidazole

Codes: S-pantoprazole sodium-043

Application context (from source-drug indications)

Gastro-oesophageal reflux diseaseS-pantoprazole sodiumPeptic ulcerS-pantoprazole sodiumHaemorrhageS-pantoprazole sodiumTrauma and injuryS-pantoprazole sodiumComaS-pantoprazole sodiumAspiration pneumoniaS-pantoprazole sodium

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
S-pantoprazole sodium	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

S-pantoprazole sodiumOptimised routesteps: 3total yield: 159g((S)-(-)-Pantoprazole sodium (API))

2-[[(4-Chloro-3-methoxypyridin-2-yl)methyl]sulfanyl]-5-(difluoromethoxy)-1H-benzimidazole→2-[[(4-Chloro-3-methoxypyridin-2-yl)methane]sulfinyl]-5-(difluoromethoxy)-1H-benzimidazole→5-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfinyl)-1H-benzimidazole

S-pantoprazole sodiumOptimised routesteps: 6total yield: 65g(Pantoprazole (Free))

3-methoxy-2-methyl-4-nitro-1-oxido-1-pyridin-1-ylium→(3-methoxy-4-nitropyridin-2-yl)methyl methanesulfonate→5-(Difluoromethoxy)-1H-benzimidazole-2-thiol→5-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfanyl)-1H-benzimidazole→4-Chloro-3-methoxy-2-methylpyridine 1-oxide→(4-chloro-3-methoxypyridin-2-yl)methyl methanesulfonate→2-[[(4-Chloro-3-methoxypyridin-2-yl)methyl]sulfanyl]-5-(difluoromethoxy)-1H-benzimidazole

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