CAS 3731-53-1

pyridin-4-ylmethanamine

Codes: APAT-006

Application context (from source-drug indications)

Breast cancerApatinib MesylateGastric cancerApatinib MesylateNon-small cell lung cancerApatinib MesylateOvarian cancerApatinib MesylatePeritoneal cancerApatinib MesylateEpithelial ovarian cancerApatinib Mesylate

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Apatinib Mesylate	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Apatinib MesylateOriginator routesteps: 5total yield: 161.5 g

1-phenylcyclopentanecarbonitrile→1-(4-nitrophenyl)cyclopentanecarbonitrile→1-(4-aminophenyl)cyclopentanecarbonitrile→2-chloronicotinoyl chloride→2-chloro-N-(4-(1-cyanocyclopentyl)phenyl)nicotinamide→pyridin-4-ylmethanamine

Intermediates available on this site

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