2-(2-Nitrophenyl)acetic acid (3740-52-1) intermediate

Application context (from source-drug indications)

Bladder cancerDocetaxel polymeric micelle (Samyang Biopharmaceuticals)Head and neck cancerDocetaxel polymeric micelle (Samyang Biopharmaceuticals)Head and neck squamous cell carcinomaDocetaxel polymeric micelle (Samyang Biopharmaceuticals)Solid tumourDocetaxel polymeric micelle (Samyang Biopharmaceuticals)Non-small cell lung cancerDocetaxel （Beihai）Prostate cancerDocetaxel （Beihai）Castration-resistant prostate cancerDocetaxel （Beihai）Breast cancerDocetaxel （Beihai）Head and neck cancerDocetaxel （Beihai）Head and neck squamous cell carcinomaDocetaxel （Beihai）Inflammatory diseaseBromfenac SodiumPostoperative painBromfenac Sodium眼睛发炎Bromfenac Sodium眼睛疼痛Bromfenac SodiumDry eye syndromeBromfenac Sodium黄斑水肿Bromfenac SodiumChemotherapy-induced nausea and vomitingGranisetronNauseaGranisetron呕吐Granisetron手术后恶心呕吐GranisetronPostoperative painGranisetronGastroparesisGranisetron

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Docetaxel polymeric micelle (Samyang Biopharmaceuticals)	Tier C — Watch / trade	-
Docetaxel （Beihai）	Tier C — Watch / trade	-
Bromfenac Sodium	Tier C — Watch / trade	-
Granisetron	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Docetaxel polymeric micelle (Samyang Biopharmaceuticals)Optimised routesteps: 4total yield: /

2-(2-Nitrophenyl)acetic acid→(2-Nitrophenyl)acetyl chloride→(2R,3S)-3-[(tert-Butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoic acid→(2R,3S)-3-[(tert-Butoxycarbonyl)amino]-2-[2-(2-nitrophenyl)acetoxy]-3-phenylpropanoic acid→(2alpha,5beta,7beta,10beta,13alpha)-4-Acetoxy-1,13-dihydroxy-9-oxo-7,10-bis[[(2,2,2-trichloroethoxy)carbonyl]oxy]-5,20-epoxytax-11-en-2-yl benzoate→(2alpha,5beta,7beta,10beta,13alpha)-4-Acetoxy-13-([(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-[2-(2-nitrophenyl)acetoxy]-3-phenylpropanoyl]oxy)-1-hydroxy-9-oxo-7,10-bis[[(2,2,2-trichloroethoxy)carbonyl]oxy]-5,20-epoxytax-11-en-2-yl benzoate

Docetaxel （Beihai）Optimised routesteps: 4total yield: /

2-(2-Nitrophenyl)acetic acid→(2-Nitrophenyl)acetyl chloride→(2R,3S)-3-[(tert-Butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoic acid→(2R,3S)-3-[(tert-Butoxycarbonyl)amino]-2-[2-(2-nitrophenyl)acetoxy]-3-phenylpropanoic acid→(2alpha,5beta,7beta,10beta,13alpha)-4-Acetoxy-1,13-dihydroxy-9-oxo-7,10-bis[[(2,2,2-trichloroethoxy)carbonyl]oxy]-5,20-epoxytax-11-en-2-yl benzoate→(2alpha,5beta,7beta,10beta,13alpha)-4-Acetoxy-13-([(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-[2-(2-nitrophenyl)acetoxy]-3-phenylpropanoyl]oxy)-1-hydroxy-9-oxo-7,10-bis[[(2,2,2-trichloroethoxy)carbonyl]oxy]-5,20-epoxytax-11-en-2-yl benzoate

Bromfenac SodiumOptimised routesteps: 2total yield: 34.3g(Bromfenac Sodium (API))

2-(4-Bromophenyl)acetonitrile→2-(2-Nitrophenyl)acetic acid→[3-(4-Bromophenyl)-2,1-benzoxazol-7-yl]acetic acid

GranisetronOptimised routesteps: 6total yield: 93.06mg(Granisetron (Free))

2-(2-Nitrophenyl)acetic acid→endo-9-Methyl-9-azabicyclo[3.3.1]nonan-3-amine→endo-N-[(1R,3r,5S)-9-Methyl-9-azabicyclo[3.3.1]nonan-3-yl]-2-(2-nitrophenyl)acetamide→endo-2-(2-Aminophenyl)-N-[(1R,3r,5S)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]acetamide→endo-N-[(1R,3r,5S)-9-Methyl-9-azabicyclo[3.3.1]nonan-3-yl]-1H-indazole-3-carboxamide→Iodomethane→1-Methyl-N-[(1R,3R,5S)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]-1H-indazole-3-carboxamide→1,2-Benzodiazole→3-(Trifluoromethyl)-1H-indazole

Intermediates available on this site

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