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CAS 376608-74-1
2-(((3aR,4S,6R,6aS)-6-((5-amino-6-chloro-2-(propylthio)pyrimidin-4-yl)amino)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethan-1-ol
Codes: TICA-029
Application context (from source-drug indications)
StrokeTicagrelorAcute coronary syndromeTicagrelorMyocardial infarctionTicagrelorPeripheral vascular diseaseTicagrelor
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Ticagrelor | Tier B — Position early | 2029 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(1R,2S)-2-(3,4-difluorophenyl)cyclopropan-1-amine→2-(((3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethan-1-ol→6-hydroxy-2-thioxo-2,3-dihydropyrimidin-4(1H)-one→1-iodopropane→2-(propylthio)pyrimidine-4,6-diol→p-toluidine→(E)-2-(propylthio)-5-(p-tolyldiazenyl)pyrimidine-4,6-diol→(E)-4,6-dichloro-2-(propylthio)-5-(p-tolyldiazenyl)pyrimidine→4,6-dichloro-2-(propylthio)-5-(2-(p-tolyl)hydrazinyl)pyrimidine→4,6-dichloro-2-(propylthio)pyrimidin-5-amine→2-(((3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethan-1-ol→2-(((3aR,4S,6R,6aS)-6-((5-amino-6-chloro-2-(propylthio)pyrimidin-4-yl)amino)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethan-1-ol→2-(((3aR,4S,6R,6aS)-6-(7-chloro-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethan-1-ol
Intermediates available on this site
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| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Qualified Partner — East China API Works | Ethanol, 2-[[(3aR,4S,6R,6aS)-6-[[5-aMino-6-chloro-2-(propylthio)-4-pyriMidinyl]aMino]tetrahydro-2,2-diMethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]- Pharmaceutical Intermediates | On request | On request | On request | — |
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