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CAS 379270-35-6
Phenyl hydrogen ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonatephenyl hydrogen ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate
Codes: Tenofovir disoproxil phosphate-051, TENO-006
Application context (from source-drug indications)
HIV infectionLamivudine/Tenofovir Disoproxil FumarateChronic hepatitis BLamivudine/Tenofovir Disoproxil FumarateHIV infectionEfavirenz/Lamivudine/Tenofovir Disoproxil FumarateHepatitis BTenofovir Alafenamide FumarateChronic hepatitis BTenofovir Alafenamide FumarateRelapsing-remitting multiple sclerosisTenofovir Alafenamide FumarateFatigueTenofovir Alafenamide FumarateHIV infectionTenofovir Alafenamide FumarateChronic hepatitis CTenofovir Alafenamide FumarateHIV infectionEmtricitabine/Rilpivirine Hydrochloride/Tenofovir Disoproxil FumarateHepatitis BTenofovir disoproxil phosphate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Lamivudine/Tenofovir Disoproxil Fumarate | Tier C — Watch / trade | - |
| Efavirenz/Lamivudine/Tenofovir Disoproxil Fumarate | Tier C — Watch / trade | - |
| Tenofovir Alafenamide Fumarate | Tier B — Position early | - |
| Emtricitabine/Rilpivirine Hydrochloride/Tenofovir Disoproxil Fumarate | Tier B — Position early | - |
| Tenofovir disoproxil phosphate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
Lamivudine/Tenofovir Disoproxil FumarateOptimised routesteps: 1total yield: 112.26g(Tenofovir disoproxil phosphate-051)
([[(2R)-1-(6-Amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonic acid→Phenyl phosphite→Phenyl hydrogen ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonate→Diphenyliodanium trifluoromethanesulfonate→Diphenyliodanium methanesulfonate→Diphenyliodanium tetrafluoridoborate(1-)→Diphenyliodonium hexafluorophosphate→Diphenyliodanium hexafluoridoarsenate(1-)→Diphenyliodanium nitrate→Diphenyliodanium fluoride→Diphenyliodanium bromide
Efavirenz/Lamivudine/Tenofovir Disoproxil FumarateOptimised routesteps: 1total yield: 112.26g(Tenofovir disoproxil phosphate-051)
([[(2R)-1-(6-Amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonic acid→Phenyl phosphite→Phenyl hydrogen ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonate→Diphenyliodanium trifluoromethanesulfonate→Diphenyliodanium methanesulfonate→Diphenyliodanium tetrafluoridoborate(1-)→Diphenyliodonium hexafluorophosphate→Diphenyliodanium hexafluoridoarsenate(1-)→Diphenyliodanium nitrate→Diphenyliodanium fluoride→Diphenyliodanium bromide
9H-purin-6-amine→(R)-4-methyl-1,3-dioxolan-2-one→(R)-1-(6-amino-9H-purin-9-yl)propan-2-ol→(diethoxyphosphoryl)methyl 4-methylbenzenesulfonate→(R)-(((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic acid→phenyl hydrogen ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate→isopropyl L-alaninate→isopropyl (((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate
Emtricitabine/Rilpivirine Hydrochloride/Tenofovir Disoproxil FumarateOptimised routesteps: 1total yield: 112.26g(Tenofovir disoproxil phosphate-051)
([[(2R)-1-(6-Amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonic acid→Phenyl phosphite→Phenyl hydrogen ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonate→Diphenyliodanium trifluoromethanesulfonate→Diphenyliodanium methanesulfonate→Diphenyliodanium tetrafluoridoborate(1-)→Diphenyliodonium hexafluorophosphate→Diphenyliodanium hexafluoridoarsenate(1-)→Diphenyliodanium nitrate→Diphenyliodanium fluoride→Diphenyliodanium bromide
Tenofovir disoproxil phosphateOptimised routesteps: 1total yield: 112.26g(Tenofovir disoproxil phosphate-051)
([[(2R)-1-(6-Amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonic acid→Phenyl phosphite→Phenyl hydrogen ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonate→Diphenyliodanium trifluoromethanesulfonate→Diphenyliodanium methanesulfonate→Diphenyliodanium tetrafluoridoborate(1-)→Diphenyliodonium hexafluorophosphate→Diphenyliodanium hexafluoridoarsenate(1-)→Diphenyliodanium nitrate→Diphenyliodanium fluoride→Diphenyliodanium bromide
Intermediates available on this site
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