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CAS 379270-37-8
isopropyl (((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate
Codes: TENO-008
Application context (from source-drug indications)
Hepatitis BTenofovir Alafenamide FumarateChronic hepatitis BTenofovir Alafenamide FumarateRelapsing-remitting multiple sclerosisTenofovir Alafenamide FumarateFatigueTenofovir Alafenamide FumarateHIV infectionTenofovir Alafenamide FumarateChronic hepatitis CTenofovir Alafenamide Fumarate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Tenofovir Alafenamide Fumarate | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
9H-purin-6-amine→(R)-4-methyl-1,3-dioxolan-2-one→(R)-1-(6-amino-9H-purin-9-yl)propan-2-ol→(diethoxyphosphoryl)methyl 4-methylbenzenesulfonate→(R)-(((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic acid→phenyl hydrogen ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate→isopropyl L-alaninate→isopropyl (((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate
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