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CAS 387-45-1
2-chloro-6-fluorobenzaldehyde2-Chloro-6-fluorobenzaldehyde
Codes: BREX-007, (I)70425-1-a
Application context (from source-drug indications)
SchizophreniaBrexpiprazoleAlzheimer's diseaseBrexpiprazoleAgitationBrexpiprazoleDepressionBrexpiprazoleDepressive disorderBrexpiprazoleMajor depressive disorderBrexpiprazoleBacterial infectionFloxacillin sodium蜂窝织炎Floxacillin sodiumChronic renal impairmentFloxacillin sodium
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Brexpiprazole | Tier A — Act now | 2029 |
| Floxacillin sodium | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-chloro-6-fluorobenzaldehyde→tert-butyl piperazine-1-carboxylate→tert-butyl 4-(3-chloro-2-formylphenyl)piperazine-1-carboxylate→ethyl 2-mercaptoacetate→tert-butyl 4-(2-(ethoxycarbonyl)benzo[b]thiophen-4-yl)piperazine-1-carboxylate→4-(4-(tert-butoxycarbonyl)piperazin-1-yl)benzo[b]thiophene-2-carboxylic acid→tert-butyl 4-(benzo[b]thiophen-4-yl)piperazine-1-carboxylate
2-chloro-6-fluorobenzaldehyde→2-thioxothiazolidin-4-one→(Z)-5-(2,6-dichlorobenzylidene)-2-thioxothiazolidin-4-one→(Z)-3-(2,6-dichlorophenyl)-2-mercaptoacrylic acid→4-chlorobenzo[b]thiophene-2-carboxylic acid→4-chlorobenzo[b]thiophene→7-hydroxyquinolin-2(1H)-one→1-bromo-4-chlorobutane→7-(4-chlorobutoxy)quinolin-2(1H)-one→1-(benzo[b]thiophen-4-yl)piperazine hydrochloride
2-Chloro-6-fluorobenzaldehyde→2-Chloro-6-fluorobenzaldehyde oxime→2-Chloro-6-fluoro-N-hydroxybenzenecarboximidoyl chloride→1-Methoxybutane-1,3-dione→Methyl 3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-carboxylate→3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-carboxylic acid→3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-carbonyl chloride→(+)-6-Aminopenicillanic acid
Intermediates available on this site
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