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CAS 3934-20-1
2,4-dichloropyrimidine2-Chloropyrimidin-4-yl chloride
Codes: OSIM-002, RILP-026, PAZO-006, (V)955428-1-a, PACR-011, (XIV) 920279-2-b, SULFA-002
Application context (from source-drug indications)
Non-small cell lung cancerOsimertinib MesylateHIV infectionRilpivirine HydrochlorideHepatic function declineRilpivirine HydrochlorideAcquired immunodeficiency syndromeRilpivirine HydrochlorideContraceptive useRilpivirine HydrochlorideRenal cell carcinomaPazopanib HydrochlorideSarcomaPazopanib HydrochlorideSoft tissue neoplasmPazopanib HydrochlorideEpistaxisPazopanib HydrochlorideHereditary haemorrhagic telangiectasiaPazopanib HydrochlorideSolitary fibrous tumourPazopanib HydrochloridePeripheral T-cell lymphomaGolidocitinibEB病毒感染GolidocitinibViral infectionGolidocitinibHistiocytosisGolidocitinib噬血细胞性淋巴组织细胞增多症GolidocitinibInterstitial lung diseaseGolidocitinibMyelofibrosisPacritinib CitrateThrombocytopeniaPacritinib CitrateAcute myeloid leukaemiaPacritinib CitrateEssential thrombocythaemiaPacritinib CitratePolycythaemia veraPacritinib CitrateChronic myelomonocytic leukaemiaPacritinib CitrateNon-small cell lung cancerLazertinib MesylateHepatic function declineLazertinib MesylateNeuroendocrine tumourSurufatinibPancreatic cancerSurufatinibNeuroendocrine carcinomaSurufatinibPancreatic neuroendocrine tumourSurufatinibIntestinal neoplasmSurufatinib阑尾肿瘤Surufatinib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Osimertinib Mesylate | Tier A — Act now | 2031 |
| Rilpivirine Hydrochloride | Tier B — Position early | - |
| Pazopanib Hydrochloride | Tier C — Watch / trade | - |
| Golidocitinib | Tier C — Watch / trade | - |
| Pacritinib Citrate | Tier C — Watch / trade | - |
| Lazertinib Mesylate | Tier C — Watch / trade | - |
| Surufatinib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1H-indole→2,4-dichloropyrimidine→3-(2-chloropyrimidin-4-yl)-1H-indole→3-(2-chloropyrimidin-4-yl)-1-methyl-1H-indole→4-fluoro-2-methoxy-5-nitroaniline→N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine→N1,N1,N2-trimethylethane-1,2-diamine→N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)-2-nitrobenzene-1,4-diamine→N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)benzene-1,2,4-triamine→acryloyl chloride→methanesulfonic acid
2,4-dichloropyrimidine→3-(2-chloropyrimidin-4-yl)-1-methyl-1H-indole→4-fluoro-2-methoxy-5-nitroaniline→N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine→N1,N1,N2-trimethylethane-1,2-diamine→N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)-2-nitrobenzene-1,4-diamine→N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)benzene-1,2,4-triamine→methanesulfonic acid→1-methyl-1H-indole→3-chloropropanoyl chloride→3-chloro-N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)propanamide
2-ethylaniline→2-ethyl-5-nitroaniline→3-methyl-6-nitro-1H-indazole→2,3-dimethyl-6-nitro-2H-indazole→2,3-dimethyl-2H-indazol-6-amine hydrochloride→2,4-dichloropyrimidine→N-(2-chloropyrimidin-4-yl)-2,3-dimethyl-2H-indazol-6-amine→N-(2-chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine→5-amino-2-methylbenzenesulfonamide
7-Nitro-1H-indole→1-(4-Methylbenzene-1-sulfonyl)-7-nitro-1H-indole→3-Bromo-1-(4-methylbenzene-1-sulfonyl)-7-nitro-1H-indole→1-(4-Methylbenzene-1-sulfonyl)-7-nitro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole→2-Chloropyrimidin-4-yl chloride→3-(2-Chloro-4-pyrimidinyl)-N-tosyl-7-nitroindole→3-(2-Chloro-4-pyrimidinyl)-7-nitroindole→3-Methoxy-1-methyl-1H-pyrazol-4-amine hydrogen chloride (1/2)→N-(3-Methoxy-1-methyl-1H-pyrazol-4-yl)-4-(7-nitro-1H-indol-3-yl)pyrimidin-2-amine→3-[2-[(3-Methoxy-1-methyl-1H-pyrazol-4-yl)amino]pyrimidin-4-yl]-1H-indol-7-amine→(2R)-2-(4-Methylpiperazin-1-yl)propanoic acid hydrogen chloride (1/2)→1-Methylpiperazine→(2S)-2-Hydroxypropanoic acid
2-hydroxy-5-nitrobenzaldehyde→1-bromo-2-chloroethane→2-(2-chloroethoxy)-5-nitrobenzaldehyde→(2-(2-chloroethoxy)-5-nitrophenyl)methanol→3-bromoprop-1-ene→2-((allyloxy)methyl)-1-(2-chloroethoxy)-4-nitrobenzene→3-((allyloxy)methyl)-4-(2-chloroethoxy)aniline→4-(3-((allyloxy)methyl)phenyl)-2-chloropyrimidine→PACR-009→pyrrolidine→2,4-dichloropyrimidine→(3-(hydroxymethyl)phenyl)boronic acid→(3-(2-chloropyrimidin-4-yl)phenyl)methanol
1-(2-Chloropyrimidin-4-yl)-3-phenyl-1H-pyrazole-4-carbaldehyde→2-Chloropyrimidin-4-yl chloride→3-Phenyl-1H-pyrazole-4-carbaldehyde
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | 3-phenyl-1H-pyrazole-4-carbaldehyde Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 4-Chloro-2-(methylsulfonyl)pyrimidine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 4-chloro-N-(2-methoxy-4-morpholino-5-nitrophenyl)pyrimidin-2-amine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 1-(2-((2-methoxy-4-morpholino-5-nitrophenyl)amino)pyrimidin-4-yl)-3-phenyl-1H-pyrazole-4-carbaldehyde Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 4-(4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)-N-(2-methoxy-4-morpholino-5-nitrophenyl)pyrimidin-2-amine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | N1-(4-(4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)pyrimidin-2-yl)-6-methoxy-4-morpholinobenzene-1,3-diamine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 4-fluoro-2-Methoxy-5-nitroaniline Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 3-(2-chloropyriMidin-4-yl)-1-Methylindole Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | N-(4-fluoro-2-Methoxy-5-nitrophenyl)-4-(1-Methylindol-3-yl)pyriMidin-2-aMine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 1,4-BenzenediaMine, N1-[2-(diMethylaMino)ethyl]-5-Methoxy-N1-Methyl-N4-[4-(1-Methyl-1H-indol-3-yl)-2-pyriMidinyl]-2-nitro- Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | N1-[2-(diMethylaMino)ethyl]-5-Methoxy-N1-Methyl-N4-[4-(1-Methyl-1H-indol-3-yl)-2-pyriMidinyl]benzene-1,2,4-triamine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | N,N,N'-Trimethylethylenediamine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 4-Methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | N-(3-Chloropropyl)morpholine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 5-hydroxy-4-methoxy-2-nitrobenzoic acid ethyl ester Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 3-Methyl-6-nitroindazole Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 2,3-Dimethyl-2H-indazol-6-amine hydrochloride Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | N-(2-chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 3-Amino-6-methylbenzenesulfonamide Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.