CAS 3958-60-9

2-Nitrobenzyl bromide

Codes: Ambroxol- 040

Application context (from source-drug indications)

Chronic bronchitisRoxithromycin/Ambroxol HydrochlorideBronchitisRoxithromycin/Ambroxol HydrochlorideRespiratory tract infectionRoxithromycin/Ambroxol HydrochloridePneumoniaRoxithromycin/Ambroxol HydrochlorideTracheitisRoxithromycin/Ambroxol HydrochlorideBacterial infectionRoxithromycin/Ambroxol HydrochlorideAnaesthesiaAmbroxol HydrochloridePharyngitisAmbroxol HydrochlorideRespiratory diseaseAmbroxol HydrochlorideBronchitisAmbroxol HydrochlorideParkinson's diseaseAmbroxol HydrochlorideParkinsonismAmbroxol Hydrochloride

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Roxithromycin/Ambroxol Hydrochloride	Tier C — Watch / trade	-
Ambroxol Hydrochloride	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Roxithromycin/Ambroxol HydrochlorideOptimised routesteps: 4total yield: 14g(Ambroxol- 005)

o-Nitrotoluene→2-Nitrobenzyl bromide→(2-Nitrophenyl)methanol→[4-(Carboxymethylidene)-2,2,6,6-tetramethylpiperidin-1-yl]oxidanyl→o-Nitrobenzaldehyde

Ambroxol HydrochlorideOptimised routesteps: 4total yield: 14g(Ambroxol- 005)

o-Nitrotoluene→2-Nitrobenzyl bromide→(2-Nitrophenyl)methanol→[4-(Carboxymethylidene)-2,2,6,6-tetramethylpiperidin-1-yl]oxidanyl→o-Nitrobenzaldehyde

Intermediates available on this site

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