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CAS 4023-34-1

cyclopropanecarbonyl chloride

Codes: OLAP-010, FILG-005

Application context (from source-drug indications)

Endometrial cancerOlaparibCastration-resistant prostate cancerOlaparibProstate cancerOlaparibPeritoneal cancerOlaparibEpithelial ovarian cancerOlaparibFallopian tube cancerOlaparibUlcerative colitisFilgotinib MaleateRheumatoid arthritisFilgotinib MaleateJuvenile rheumatoid arthritisFilgotinib MaleateCrohn's diseaseFilgotinib Maleate狼疮肾炎Filgotinib MaleateBehçet's syndromeFilgotinib Maleate

Source drugs (routes using this intermediate)

DrugTierExpiry
OlaparibTier A — Act now2028
Filgotinib MaleateTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

OlaparibOriginator routesteps: 6total yield: 1.27 kg
3-hydroxyisobenzofuran-1(3H)-one→dimethyl phosphonate→dimethyl (3-oxo-1,3-dihydroisobenzofuran-1-yl)phosphonate→2-fluoro-5-formylbenzonitrile→(Z)-2-fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile→2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid→tert-butyl piperazine-1-carboxylate→tert-butyl 4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazine-1-carboxylate→4-(4-fluoro-3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one→cyclopropanecarbonyl chloride
OlaparibOptimised routesteps: 6total yield: 8.67 g
3-hydroxyisobenzofuran-1(3H)-one→2-fluoro-5-formylbenzonitrile→(Z)-2-fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile→2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid→cyclopropanecarbonyl chloride→2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzonitrile→cyclopropyl(piperazin-1-yl)methanone hydrochloride→piperazine
Filgotinib MaleateOriginator routesteps: 6total yield: /
6-bromopyridin-2-amine→O-ethyl carbonisothiocyanatidate→FILG-003→FILG-004→cyclopropanecarbonyl chloride→N-(5-bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide→(4-(hydroxymethyl)phenyl)boronic acid→FILG-008→FILG-009→thiomorpholine 1,1-dioxide
Filgotinib MaleateOptimised routesteps: 8total yield: /
O-ethyl carbonisothiocyanatidate→cyclopropanecarbonyl chloride→FILG-011→FILG-012→tert-butyl (6-hydroxypyridin-2-yl)carbamate→FILG-014→FILG-015→FILG-016→FILG-017→FILG-018→FILG-019

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

SupplierProductPrice bandMOQLead timeQualificationsAction
Unibest Nantong cGMP Site5-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine
Pharmaceutical Intermediates
On requestOn requestOn request
—
Unibest Taizhou GMP-like SiteThiomorpholine-1,1-dioxide
Pharmaceutical Intermediates
On requestOn requestOn request
—
Qualified Partner — East China API WorksTHIOMORPHOLINE 1,1-DIOXIDE HYDROCHLORIDE
Pharmaceutical Intermediates
On requestOn requestOn request
—
Unibest Nantong cGMP Site2-Fluoro-5-formylbenzonitrile
Pharmaceutical Intermediates
On requestOn requestOn request
—
Unibest Taizhou GMP-like Site2-Fluoro-5-[(3-oxo-1(3H)-isobenzofuranylidene)methyl]benzonitrile
Pharmaceutical Intermediates
On requestOn requestOn request
—
Qualified Partner — East China API Works2-fluoro-5-((4-oxo-3,4-dihydrophthalazin -1-yl)Methyl)benzoic acid
Pharmaceutical Intermediates
On requestOn requestOn request
—
Unibest Nantong cGMP Site1-(Cyclopropylcarbonyl)piperazine hydrochloride
Pharmaceutical Intermediates
On requestOn requestOn request
—
Unibest Taizhou GMP-like Site3-oxo-1,3-dihydroisobenzofuran-1-ylphosphonic acid
Pharmaceutical Intermediates
On requestOn requestOn request
—

This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.