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CAS 40371-52-6
(S)-2,5-dioxopyrrolidin-1-yl 4-(((benzyloxy)carbonyl)amino)-2-hydroxybutanoate
Codes: PLAZ-013
Application context (from source-drug indications)
Bacterial infectionPlazomicin sulfateHospital-acquired pneumoniaPlazomicin sulfateUrinary tract infectionPlazomicin sulfatePyelonephritisPlazomicin sulfateEnd-stage renal diseasePlazomicin sulfate肠杆菌科感染Plazomicin sulfate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Plazomicin sulfate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
benzyl (2,5-dioxopyrrolidin-1-yl) carbonate→D-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1->6)-O-[2,3,4,6-tetradeoxy-...]-2-deoxy-N3-[(phenylmethoxy)carbonyl]-→(S)-2,5-dioxopyrrolidin-1-yl 4-(((benzyloxy)carbonyl)amino)-2-hydroxybutanoate→PLAZ-014→2-oxoethyl benzoate→2-((((2S,3R)-3-(((benzyloxy)carbonyl)amino)-2-(((1R,2S,3S,4R,6S)-6-(((benzyloxy)carbonyl)amino)-4-((S)-4-(((benzyloxy)carbonyl)amino)-2-hydroxybutanamido)-3-(((2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)tetrahydro-2H-pyran-2-yl)oxy)-2-hydroxycyclohexyl)oxy)-3,4-dihydro-2H-pyran-6-yl)methyl)amino)ethyl benzoate
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