CAS 42017-89-0

2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoic acid

Codes: FENOF-002, Fenofibric acid

Application context (from source-drug indications)

DyslipidaemiaFenofibrate/SimvastatinHyperlipidaemiaFenofibrate/SimvastatinCardiac and vascular disordersFenofibrate/SimvastatinHypercholesterolaemiaFenofibrate/SimvastatinHypercholesterolaemiaFenofibric acidHypertriglyceridaemiaFenofibric acidHyperlipidaemiaFenofibric acidDyslipidaemiaFenofibric acidHypercholesterolaemiaFenofibrateHypertriglyceridaemiaFenofibrateBiliary cirrhosisFenofibrateDiabetic retinopathyFenofibrateSepsisFenofibrateType 1 diabetesFenofibrate

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Fenofibrate/Simvastatin	Tier C — Watch / trade	-
Fenofibric acid	Tier C — Watch / trade	-
Fenofibrate	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Fenofibrate/SimvastatinOptimised routesteps: 2total yield: /

(4-chlorophenyl)(4-hydroxyphenyl)methanone→2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoic acid

Fenofibric acidOriginator routesteps: 3total yield: 1.1 kg (Fenofibric acid)

4-chlorobenzoyl chloride→(4-chlorophenyl)(4-methoxyphenyl)methanone→(4-chlorophenyl)(4-hydroxyphenyl)methanone→Fenofibric acid

FenofibrateOptimised routesteps: 2total yield: /

(4-chlorophenyl)(4-hydroxyphenyl)methanone→2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoic acid

Intermediates available on this site

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