← Back to patent-cliff list
CAS 438056-69-0
4-(4-aminophenyl)morpholin-3-one
Codes: RIVA-008
Application context (from source-drug indications)
Pulmonary embolismRivaroxabanStrokeRivaroxabanCongenital heart defectRivaroxabanThrombosisRivaroxabanVenous thromboembolismRivaroxabanCoronary artery diseaseRivaroxaban
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Rivaroxaban | Tier A — Act now | 2026 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-aminoethan-1-ol→2-chloroacetyl chloride→2-(2-chloroacetamido)ethyl 2-chloroacetate→2-chloro-N-(2-hydroxyethyl)acetamide→morpholin-3-one→1-fluoro-4-nitrobenzene→4-(4-nitrophenyl)morpholin-3-one→4-(4-aminophenyl)morpholin-3-one→(S)-2-(oxiran-2-ylmethyl)isoindoline-1,3-dione→(R)-2-(2-hydroxy-3-((4-(3-oxomorpholino)phenyl)amino)propyl)isoindoline-1,3-dione→(S)-2-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione→(S)-4-(4-(5-(aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one oxalate→5-chlorothiophene-2-carbonyl chloride
4-(4-aminophenyl)morpholin-3-one→5-chlorothiophene-2-carbonyl chloride→5-chlorothiophene-2-carbaldehyde→5-chlorothiophene-2-carboxylic acid→(S)-3-aminopropane-1,2-diol hydrochloride→(S)-5-chloro-N-(2,3-dihydroxypropyl)thiophene-2-carboxamide→(S)-N-(3-bromo-2-hydroxypropyl)-5-chlorothiophene-2-carboxamide→(R)-5-chloro-N-(2-hydroxy-3-((4-(3-oxomorpholino)phenyl)amino)propyl)thiophene-2-carboxamide
2-chloroacetyl chloride→4-(4-nitrophenyl)morpholin-3-one→4-(4-aminophenyl)morpholin-3-one→5-chlorothiophene-2-carbonyl chloride→2-(phenylamino)ethan-1-ol→4-phenylmorpholin-3-one→benzyl carbonochloridate→benzyl (4-(3-oxomorpholino)phenyl)carbamate→(R)-oxiran-2-ylmethyl butyrate→(R)-4-(4-(5-(hydroxymethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one→(R)-(2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl methanesulfonate→2-methylpropan-2-amine→(S)-4-(4-(5-((tert-butylamino)methyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one→(S)-N-(tert-butyl)-5-chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)thiophene-2-carboxamide
4-(4-aminophenyl)morpholin-3-one→5-chlorothiophene-2-carbonyl chloride→(R)-4-(4-(5-(hydroxymethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one→(S)-3-(benzyloxy)-2-hydroxypropyl 4-methylbenzenesulfonate→(S)-1-(benzyloxy)-3-(tosyloxy)propan-2-yl acetate→(R)-1-(benzyloxy)-3-((4-(3-oxomorpholino)phenyl)amino)propan-2-yl acetate→(R)-1-(benzyloxy)-3-((chlorocarbonyl)(4-(3-oxomorpholino)phenyl)amino)propan-2-yl acetate→(R)-4-(4-(5-((benzyloxy)methyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one→(R)-(2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl 4-methylbenzenesulfonate→(S)-4-(4-(5-((benzylamino)methyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one→(S)-N-benzyl-5-chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)thiophene-2-carboxamide
4-(4-aminophenyl)morpholin-3-one→5-chlorothiophene-2-carbaldehyde→(S)-2-(chloromethyl)oxirane→(S)-1-azido-3-chloropropan-2-ol→(S)-2-(azidomethyl)oxirane→(R)-4-(4-((3-azido-2-hydroxypropyl)amino)phenyl)morpholin-3-one→(R)-4-(4-(5-(azidomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one→(S)-4-(4-(5-(aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Qualified Partner — East China API Works | 4-(4-Aminophenyl)morpholin -3-one Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.