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CAS 461699-13-8
tert-butyl 3-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
Codes: Rilza-004
Application context (from source-drug indications)
Immune thrombocytopenic purpuraRilzabrutinib免疫球蛋白G4相关疾病RilzabrutinibAutoimmune haemolytic anaemiaRilzabrutinibSickle cell diseaseRilzabrutinib格雷夫斯病RilzabrutinibAsthmaRilzabrutinib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Rilzabrutinib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1H-pyrazolo[3,4-d]pyrimidin-4-amine→3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine→tert-butyl (R)-3-hydroxypiperidine-1-carboxylate→tert-butyl 3-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate→2-fluoro-4-phenoxyphenylboronic acid→tert-butyl 3-(4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate→3-(2-fluoro-4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine→3-(3-(4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-3-oxopropanenitrile→2-methyl-2-(4-(oxetan-3-yl)piperazin-1-yl)propanal→4-bromo-3-fluorophenol→phenylboronic acid→1-bromo-2-fluoro-4-phenoxybenzene→2-bromo-2-methylpropanal→1-(oxetan-3-yl)piperazine
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Qualified Partner — East China API Works | (2-fluoro-4-phenoxyphenyl)boronic acid Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | Benzyl 4-(oxetan-3-yl)piperazine-1-carboxylate Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.