CAS 4637-24-5

(Dimethylamino)formaldehyde dimethyl acetal1,1-dimethoxy-N,N-dimethylmethanamineN,N-Dimethylformamide dimethyl acetal

Codes: (VII)461018-3-a, IGUR-018, Bromfenac Sodium-031

Application context (from source-drug indications)

Waldenström macroglobulinaemiaIbrutinibChronic lymphocytic leukaemiaIbrutinibMantle cell lymphomaIbrutinibGraft-versus-host diseaseIbrutinibRheumatoid arthritisIguratimodGraft-versus-host diseaseIguratimodSjögren's syndromeIguratimodInflammatory diseaseBromfenac SodiumPostoperative painBromfenac Sodium眼睛发炎Bromfenac Sodium眼睛疼痛Bromfenac SodiumDry eye syndromeBromfenac Sodium黄斑水肿Bromfenac Sodium

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Ibrutinib	Tier A — Act now	2027
Iguratimod	Tier C — Watch / trade	-
Bromfenac Sodium	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

IbrutinibOptimised routesteps: 4total yield: /

4-Phenoxybenzoyl chloride→1,1-Dicyanomethane→(4-Phenoxybenzoyl)malononitrile→1,1-Dicyano-2-methoxy-2-(4-phenoxyphenyl)ethene→1-[(3R)-3-Hydrazinopiperidin-1-yl]prop-2-en-1-one→1-[(3R)-1-Acryloylpiperidin-3-yl]-5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile→(Dimethylamino)formaldehyde dimethyl acetal

IguratimodProcess routesteps: 7total yield: 3.01 kg

1-chloro-4-methoxy-2-nitrobenzene→phenol→4-methoxy-2-nitro-1-phenoxybenzene→5-methoxy-2-phenoxyaniline→N-(5-methoxy-2-phenoxyphenyl)methanesulfonamide→2-aminoacetonitrile hydrochloride→N-(4-glycyl-5-methoxy-2-phenoxyphenyl)methanesulfonamide→N-(2-(2-methoxy-4-(methylsulfonamido)-5-phenoxyphenyl)-2-oxoethyl)formamide→N-(2-(2-hydroxy-4-(methylsulfonamido)-5-phenoxyphenyl)-2-oxoethyl)formamide→1,1-dimethoxy-N,N-dimethylmethanamine

Bromfenac SodiumOptimised routesteps: 4total yield: 83.27g(Bromfenac Sodium (API))

1-Ethyl-2-nitrobenzene→2-Ethylaniline→4-Bromobenzoyl chloride→(2-Amino-3-ethylphenyl)(4-bromophenyl)methanone→N,N-Dimethylformamide dimethyl acetal→[2-Amino-3-[3-(dimethylamino)prop-2-en-1-yl]phenyl](4-bromophenyl)methanone

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications
Unibest Taizhou GMP-like Site	N-(4-glycyl-5-methoxy-2-phenoxyphenyl)methanesulfonamide hydrochloride Pharmaceutical Intermediates	On request	On request	On request	—
Qualified Partner — East China API Works	N-(5-Methoxy-2-phenoxyphenyl)methanesulfonamide Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Nantong cGMP Site	N-[4-[(Formylamino)acetyl] -5-hydroxy-2- phenoxyphenyl]methanesulfonamide Pharmaceutical Intermediates	On request	On request	On request	—

This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.