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CAS 474944-31-5
(S)-3-((tert-butyldimethylsilyl)oxy)-5-phenylpentan-1-ol
Codes: LATA-016
Application context (from source-drug indications)
Ocular hypertensionCarteolol Hydrochloride/LatanoprostGlaucomaCarteolol Hydrochloride/LatanoprostOpen-angle glaucomaCarteolol Hydrochloride/LatanoprostOcular hypertensionLatanoprostOpen-angle glaucomaLatanoprostVitiligoLatanoprostAlopecia areataLatanoprostGlaucomaLatanoprostPtosisLatanoprost
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Carteolol Hydrochloride/Latanoprost | Tier C — Watch / trade | - |
| Latanoprost | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(3aR,4R,5R,6aS)-4-((R)-3-hydroxy-5-phenylpentyl)hexahydro-2H-cyclopenta[b]furan-2,5-diol→(4-carboxybutyl)triphenylphosphonium bromide→(Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoic acid→2-iodopropane→allyl acetate→3-phenylpropan-1-ol→(S)-1-phenylhex-5-en-3-ol→(S)-tert-butyldimethyl((1-phenylhex-5-en-3-yl)oxy)silane→(S)-3-((tert-butyldimethylsilyl)oxy)-5-phenylpentan-1-ol→(S)-tert-butyl((1-iodo-5-phenylpentan-3-yl)oxy)dimethylsilane→thiophene→LATA-019→(3aR,6aS)-2-methoxy-3,3a,6,6a-tetrahydro-2H-cyclopenta[b]furan-5-carbaldehyde→tert-butyl(((3R)-1-((3aR,4R,6aS,Z)-2-methoxy-5-(((trimethylsilyl)oxy)methylene)hexahydro-2H-cyclopenta[b]furan-4-yl)-5-phenylpentan-3-yl)oxy)dimethylsilane→(3aR,4R,5R,6aS)-4-((R)-3-((tert-butyldimethylsilyl)oxy)-5-phenylpentyl)-2-methoxyhexahydro-2H-cyclopenta[b]furan-5-ol
(3aR,4R,5R,6aS)-4-((R)-3-hydroxy-5-phenylpentyl)hexahydro-2H-cyclopenta[b]furan-2,5-diol→(4-carboxybutyl)triphenylphosphonium bromide→(Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoic acid→2-iodopropane→allyl acetate→3-phenylpropan-1-ol→(S)-1-phenylhex-5-en-3-ol→(S)-tert-butyldimethyl((1-phenylhex-5-en-3-yl)oxy)silane→(S)-3-((tert-butyldimethylsilyl)oxy)-5-phenylpentan-1-ol→(S)-tert-butyl((1-iodo-5-phenylpentan-3-yl)oxy)dimethylsilane→thiophene→LATA-019→(3aR,6aS)-2-methoxy-3,3a,6,6a-tetrahydro-2H-cyclopenta[b]furan-5-carbaldehyde→tert-butyl(((3R)-1-((3aR,4R,6aS,Z)-2-methoxy-5-(((trimethylsilyl)oxy)methylene)hexahydro-2H-cyclopenta[b]furan-4-yl)-5-phenylpentan-3-yl)oxy)dimethylsilane→(3aR,4R,5R,6aS)-4-((R)-3-((tert-butyldimethylsilyl)oxy)-5-phenylpentyl)-2-methoxyhexahydro-2H-cyclopenta[b]furan-5-ol
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