← Back to patent-cliff list
CAS 4771-80-6
cyclohex-3-ene-1-carboxylic acid
Codes: EDOX-001, LEFA-006
Application context (from source-drug indications)
Pulmonary embolismEdoxaban Tosilate HydrateVenous thromboembolismEdoxaban Tosilate HydrateStrokeEdoxaban Tosilate HydrateEmbolismEdoxaban Tosilate HydrateVenous thrombosisEdoxaban Tosilate HydrateIschaemic strokeEdoxaban Tosilate HydrateInfectionLefamulinCommunity-acquired infectionLefamulinBacterial pneumoniaLefamulinPneumoniaLefamulinCommunity-acquired pneumoniaLefamulinCystic fibrosisLefamulin
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Edoxaban Tosilate Hydrate | Tier B — Position early | 2028 |
| Lefamulin | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
cyclohex-3-ene-1-carboxylic acid→(S)-cyclohex-3-ene-1-carboxylic acid→(1S,4S,5S)-4-iodo-6-oxabicyclo[3.2.1]octan-7-one→ethyl (1S,3S,6R)-7-oxabicyclo[4.1.0]heptane-3-carboxylate→ethyl (1S,3R,4R)-3-azido-4-hydroxycyclohexane-1-carboxylate→ethyl (1S,3R,4R)-3-((tert-butoxycarbonyl)amino)-4-hydroxycyclohexane-1-carboxylate→ethyl (1S,3R,4S)-4-azido-3-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylate→(1S,3R,4S)-4-azido-3-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylic acid→tert-butyl ((1R,2S,5S)-2-azido-5-(dimethylcarbamoyl)cyclohexyl)carbamate→(1S,3R,4S)-3-amino-4-azido-N,N-dimethylcyclohexane-1-carboxamide→lithium 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylate→N-((1R,2S,5S)-2-azido-5-(dimethylcarbamoyl)cyclohexyl)-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide→N-((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide→sodium 2-((5-chloropyridin-2-yl)amino)-2-oxoacetate
(3aR,4R,5R,7S,8S,9R,9aS,12R)-8-hydroxy-4,7,9,12-tetramethyl-3-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-5-yl 2-(((1R,2R,4R)-4-((tert-butoxycarbonyl)amino)-2-hydroxycyclohexyl)thio)acetate→cyclohex-3-ene-1-carboxylic acid→(S)-1-phenylethan-1-amine→(S)-1-phenylethan-1-aminium (R)-cyclohex-3-ene-1-carboxylate→(R)-cyclohex-3-ene-1-carboxylic acid→tert-butyl (R)-cyclohex-3-en-1-ylcarbamate→tert-butyl ((1R,3R,6S)-7-oxabicyclo[4.1.0]heptan-3-yl)carbamate→S-((1R,2R,4R)-4-((tert-butoxycarbonyl)amino)-2-hydroxycyclohexyl) benzothioate→tert-butyl ((1R,3R,4R)-3-hydroxy-4-mercaptocyclohexyl)carbamate→(3aR,4R,5R,7S,8S,9R,9aS,12R)-8-hydroxy-4,7,9,12-tetramethyl-3-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-5-yl 2-(tosyloxy)acetate
Intermediates available on this site
No listed intermediates for this target yet — send an RFQ directly and it will enter our matching pool.
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.