CAS 502496-33-5

1-bromo-5-fluoro-2-methyl-3-nitrobenzene

Codes: LOU-064-009

Application context (from source-drug indications)

Chronic urticariaRemibrutinibUrticariaRemibrutinib花生过敏Remibrutinib鸡蛋过敏Remibrutinib乳类过敏反应Remibrutinib食物过敏Remibrutinib

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Remibrutinib	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

RemibrutinibOriginator routesteps: 10total yield: 2.80 g (LOU-064)

4,6-dichloro-5-methoxypyrimidine→6-chloro-5-methoxypyrimidin-4-amine→4-amino-6-chloropyrimidin-5-ol→tert-butyl (2-hydroxyethyl)(methyl)carbamate→tert-butyl (2-((4-amino-6-chloropyrimidin-5-yl)oxy)ethyl)(methyl)carbamate→4-cyclopropyl-2-fluoro-N-(5-fluoro-2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)benzamide→tert-butyl (2-((4-amino-6-(3-(4-cyclopropyl-2-fluorobenzamido)-5-fluoro-2-methylphenyl)pyrimidin-5-yl)oxy)ethyl)(methyl)carbamate→N-(3-(6-amino-5-(2-(methylamino)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluorobenzamide 2,2,2-trifluoroacetate→1-bromo-5-fluoro-2-methyl-3-nitrobenzene→2-(5-fluoro-2-methyl-3-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane→5-fluoro-2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline→methyl 4-cyclopropyl-2-fluorobenzoate→methyl 4-bromo-2-fluorobenzoate→cyclopropylboronic acid

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications	Action
Unibest Nantong cGMP Site	1-broMo-5-fluoro-2-Methyl-3-nitrobenzene Pharmaceutical Intermediates	On request	On request	On request	—

This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.