CAS 504-24-5

pyridin-4-amine

Codes: EDOX-015, AMIF-005

Application context (from source-drug indications)

Pulmonary embolismEdoxaban Tosilate HydrateVenous thromboembolismEdoxaban Tosilate HydrateStrokeEdoxaban Tosilate HydrateEmbolismEdoxaban Tosilate HydrateVenous thrombosisEdoxaban Tosilate HydrateIschaemic strokeEdoxaban Tosilate HydrateLambert-Eaton myasthenic syndromeAmifampridine PhosphateSpinal muscular atrophyAmifampridine PhosphateMyasthenia gravisAmifampridine PhosphatePaediatric spinal muscular atrophyAmifampridine PhosphateCongenital myasthenic syndromeAmifampridine PhosphateMultiple sclerosisAmifampridine Phosphate

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Edoxaban Tosilate Hydrate	Tier B — Position early	2028
Amifampridine Phosphate	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Edoxaban Tosilate HydrateOptimised routesteps: 5total yield: /

lithium 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylate→pyridin-4-amine→tert-butyl pyridin-4-ylcarbamate→tert-butyl (3-mercaptopyridin-4-yl)carbamate→thiazolo[5,4-c]pyridine→5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine

Amifampridine PhosphateOptimised routesteps: 4total yield: 535 mg

3-nitropyridin-4-amine→pyridin-4-amine→N-(3-nitropyridin-4-yl)acetamide→N-(pyridin-4-yl)acetamide

Intermediates available on this site

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