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CAS 50824-05-0
1-(bromomethyl)-4-(trifluoromethoxy)benzene
Codes: PRET-007, ELISME-005
Application context (from source-drug indications)
Mycobacterium tuberculosis infectionPretomanidMultidrug-resistant tuberculosisPretomanidPulmonary tuberculosisPretomanidExtensively drug-resistant tuberculosisPretomanidRenal impairmentPretomanidMigraineElismetrep糖尿病周围神经病变ElismetrepHot flushesElismetrepVasomotor symptomsElismetrep
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Pretomanid | Tier C — Watch / trade | - |
| Elismetrep | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2,4-dinitro-1H-imidazole→(S)-tert-butyldimethyl(oxiran-2-ylmethoxy)silane→(S)-1-((tert-butyldimethylsilyl)oxy)-3-(2,4-dinitro-1H-imidazol-1-yl)propan-2-ol→1-((2S)-3-((tert-butyldimethylsilyl)oxy)-2-((tetrahydro-2H-pyran-2-yl)oxy)propyl)-2,4-dinitro-1H-imidazole→(6S)-2-nitro-6-((tetrahydro-2H-pyran-2-yl)oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine→(S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-ol→1-(bromomethyl)-4-(trifluoromethoxy)benzene
2,4-dinitro-1H-imidazole→(6S)-2-nitro-6-((tetrahydro-2H-pyran-2-yl)oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine→(S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-ol→1-(bromomethyl)-4-(trifluoromethoxy)benzene→1H-imidazole→4-nitro-1H-imidazole→1,4-dinitro-1H-imidazole→(S)-oxiran-2-ylmethyl butyrate→(S)-3-(2,4-dinitro-1H-imidazol-1-yl)-2-hydroxypropyl butyrate→(2S)-3-(2,4-dinitro-1H-imidazol-1-yl)-2-((tetrahydro-2H-pyran-2-yl)oxy)propyl butyrate
isoquinolin-3-amine→ethyl 4-(chlorosulfonyl)benzoate→ethyl 4-(N-(isoquinolin-3-yl)sulfamoyl)benzoate→ethyl 4-(N-(4-iodoisoquinolin-3-yl)sulfamoyl)benzoate→1-(bromomethyl)-4-(trifluoromethoxy)benzene→ethyl 4-(N-(4-iodoisoquinolin-3-yl)-N-(4-(trifluoromethoxy)benzyl)sulfamoyl)benzoate→cyclopropylboronic acid→ethyl 4-(N-(4-cyclopropylisoquinolin-3-yl)-N-(4-(trifluoromethoxy)benzyl)sulfamoyl)benzoate→Elismetrep
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