CAS 52-90-4

Plant-derived natural amino-acid L-cysteineL-Cysteine

Codes: Reduced Glutathione Sodium-002, Cilastatin Sodium-008

Application context (from source-drug indications)

Acute respiratory distress syndromeReduced Glutathione SodiumLiver diseaseReduced Glutathione Sodium酒精性肝炎Reduced Glutathione Sodium酒精性肝硬化Reduced Glutathione Sodium酒精性脂肪肝病Reduced Glutathione SodiumSepsisReduced Glutathione SodiumInfectious diseaseCilastatin Sodium

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Reduced Glutathione Sodium	Tier C — Watch / trade	-
Cilastatin Sodium	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Reduced Glutathione SodiumOptimised routesteps: 1total yield: 224mg(Reduced Glutathione Sodium (Free))

(S)-(+)-Glutamic acid→Plant-derived natural amino-acid L-cysteine→Aminoethanoic acid

Cilastatin SodiumOptimised routesteps: 5total yield: 95g(Cilastatin Sodium (Free))

Ethyl 1,3-dithiane-2-carboxylate→Pentamethylene dibromide→ethyl 2-(5-bromopentyl)-1,3-dithiane-2-carboxylate→Ethyl 7-bromo-2-oxoheptanoate→7-bromo-2-oxoheptanoic acid→(+)-(1S)-2,2-Dimethylcyclopropanecarboxamide→(2Z)-7-Bromo-2-([[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino)hept-2-enoic acid→Plant-derived natural amino-acid L-cysteine

Cilastatin SodiumOptimised routesteps: 6total yield: 20.8g(Cilastatin Sodium (API))

1-Bromo-5-chloropentane→Ethyl 2-ethoxy-2-oxoacetate→7-Chloro-2-oxoheptanoic acid ethyl ester→Ethyl 7-bromo-2-oxoheptanoate→Butyl 7-chloro-2-oxoheptanoate→2,2-Dimethylcyclopropane-1(S)-carboxamide→7-Chloro-2-[(1S)-2,2-dimethylcyclopropylcarboxamido]-2-heptenoic acid ethyl ester→Ethyl (2Z)-7-bromo-2-([[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino)hept-2-enoate→Butyl (2Z)-7-chloro-2-[[(1S)-2,2-dimethylcyclopropane-1-carbonyl]amino]hept-2-enoate→(2Z)-7-Chloro-2-([[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino)hept-2-enoic acid→(2Z)-7-Bromo-2-([[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino)hept-2-enoic acid→L-Cysteine→(2Z)-7-[[(2R)-2-Amino-2-carboxyethyl]sulfanyl]-2-([[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino)hept-2-enoic acid

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