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CAS 53-43-0
(3S,8R,9S,10R,13S,14S)-3-hydroxy-10,13-dimethyl-3,4,7,8,9,10,11,12,13,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17(2H)-one
Codes: ISTA-001
Application context (from source-drug indications)
Cardiogenic shockIstaroximeHeart failureIstaroximeAcute decompensated heart failureIstaroxime
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Istaroxime | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(3S,8R,9S,10R,13S,14S)-3-hydroxy-10,13-dimethyl-3,4,7,8,9,10,11,12,13,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17(2H)-one→(3S,8R,9S,10R,13S,14S)-3-((tert-butyldimethylsilyl)oxy)-10,13-dimethyl-1,2,3,4,7,8,9,10,11,12,13,14,15,16-tetradecahydro-17H-cyclopenta[a]phenanthren-17-one→(3S,8R,9S,10R,13S,14S,17S)-3-((tert-butyldimethylsilyl)oxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-ol→(3S,5S,6S,8R,9S,10R,13S,14S,17S)-3-((tert-butyldimethylsilyl)oxy)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-6,17-diol→(3S,5S,6S,8R,9S,10R,13S,14S,17S)-3-((tert-butyldimethylsilyl)oxy)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-6,17-diyl diacetate→(3S,5S,6S,8R,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-6,17-diyl diacetate→2-iodosylbenzoic acid→(5S,6S,8R,9S,10R,13S,14S,17S)-10,13-dimethyl-3-oxohexadecahydro-1H-cyclopenta[a]phenanthrene-6,17-diyl diacetate→(5S,6S,8R,9S,10R,13S,14S,17S)-6,17-dihydroxy-10,13-dimethylhexadecahydro-3H-cyclopenta[a]phenanthren-3-one→2-(aminooxy)ethanamine→(5S,6S,8R,9S,10R,13S,14S,17S,E)-6,17-dihydroxy-10,13-dimethylhexadecahydro-3H-cyclopenta[a]phenanthren-3-one O-(2-aminoethyl) oxime
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