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CAS 534-07-6
1,3-dichloropropan-2-one
Codes: RITO-022
Application context (from source-drug indications)
Chronic hepatitis CParitaprevir/Ombitasvir/RitonavirHepatitis CParitaprevir/Ombitasvir/RitonavirDecompensated cirrhosisParitaprevir/Ombitasvir/RitonavirRenal impairmentParitaprevir/Ombitasvir/RitonavirFibrosisParitaprevir/Ombitasvir/RitonavirEnd-stage renal diseaseParitaprevir/Ombitasvir/RitonavirHIV infectionDarunavir Ethanolate/RitonavirHIV infectionRitonavirKaposi's sarcomaRitonavirBreast cancerRitonavir
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Paritaprevir/Ombitasvir/Ritonavir | Tier C — Watch / trade | - |
| Darunavir Ethanolate/Ritonavir | Tier C — Watch / trade | - |
| Ritonavir | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(S)-benzyl (1-hydroxy-3-phenylpropan-2-yl)carbamate→(S)-benzyl (1-oxo-3-phenylpropan-2-yl)carbamate→dibenzyl ((2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl)dicarbamate→1-bromo-2-methyl-1-oxopropan-2-yl acetate→(5S,6R,7R,8S)-5,8-dibenzyl-7-bromo-3,10-dioxo-1,12-diphenyl-2,11-dioxa-4,9-diazadodecan-6-yl acetate→dibenzyl ((1S,1'S)-((2R,3R)-oxirane-2,3-diyl)bis(2-phenylethane-1,1-diyl))dicarbamate→dibenzyl ((2S,3S,5S)-3-hydroxy-1,6-diphenylhexane-2,5-diyl)dicarbamate→(2S,3S,5S)-2,5-diamino-1,6-diphenylhexan-3-ol→phenylboronic acid→(S)-1-((4S,6S)-4-benzyl-2-phenyl-1,3,2-oxazaborinan-6-yl)-2-phenylethanamine→4-nitrophenyl (thiazol-5-ylmethyl) carbonate→thiazol-5-ylmethyl ((2S,3S,5S)-5-amino-3-hydroxy-1,6-diphenylhexan-2-yl)carbamate→(S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoic acid→ethyl 2-chloroacetate→ethyl 2-chloro-3-oxopropanoate→methanethioamide→ethyl thiazole-5-carboxylate→thiazol-5-ylmethanol→4-nitrophenyl carbonochloridate→isobutyramide→2-methylpropanethioamide→1,3-dichloropropan-2-one→methyl L-valinate hydrochloride→1-(2-isopropylthiazol-4-yl)-N-methylmethanamine→RITO-025→(S)-methyl 2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoate
(S)-benzyl (1-hydroxy-3-phenylpropan-2-yl)carbamate→(S)-benzyl (1-oxo-3-phenylpropan-2-yl)carbamate→dibenzyl ((2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl)dicarbamate→1-bromo-2-methyl-1-oxopropan-2-yl acetate→(5S,6R,7R,8S)-5,8-dibenzyl-7-bromo-3,10-dioxo-1,12-diphenyl-2,11-dioxa-4,9-diazadodecan-6-yl acetate→dibenzyl ((1S,1'S)-((2R,3R)-oxirane-2,3-diyl)bis(2-phenylethane-1,1-diyl))dicarbamate→dibenzyl ((2S,3S,5S)-3-hydroxy-1,6-diphenylhexane-2,5-diyl)dicarbamate→(2S,3S,5S)-2,5-diamino-1,6-diphenylhexan-3-ol→phenylboronic acid→(S)-1-((4S,6S)-4-benzyl-2-phenyl-1,3,2-oxazaborinan-6-yl)-2-phenylethanamine→4-nitrophenyl (thiazol-5-ylmethyl) carbonate→thiazol-5-ylmethyl ((2S,3S,5S)-5-amino-3-hydroxy-1,6-diphenylhexan-2-yl)carbamate→(S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoic acid→ethyl 2-chloroacetate→ethyl 2-chloro-3-oxopropanoate→methanethioamide→ethyl thiazole-5-carboxylate→thiazol-5-ylmethanol→4-nitrophenyl carbonochloridate→isobutyramide→2-methylpropanethioamide→1,3-dichloropropan-2-one→methyl L-valinate hydrochloride→1-(2-isopropylthiazol-4-yl)-N-methylmethanamine→RITO-025→(S)-methyl 2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoate
(S)-benzyl (1-hydroxy-3-phenylpropan-2-yl)carbamate→(S)-benzyl (1-oxo-3-phenylpropan-2-yl)carbamate→dibenzyl ((2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl)dicarbamate→1-bromo-2-methyl-1-oxopropan-2-yl acetate→(5S,6R,7R,8S)-5,8-dibenzyl-7-bromo-3,10-dioxo-1,12-diphenyl-2,11-dioxa-4,9-diazadodecan-6-yl acetate→dibenzyl ((1S,1'S)-((2R,3R)-oxirane-2,3-diyl)bis(2-phenylethane-1,1-diyl))dicarbamate→dibenzyl ((2S,3S,5S)-3-hydroxy-1,6-diphenylhexane-2,5-diyl)dicarbamate→(2S,3S,5S)-2,5-diamino-1,6-diphenylhexan-3-ol→phenylboronic acid→(S)-1-((4S,6S)-4-benzyl-2-phenyl-1,3,2-oxazaborinan-6-yl)-2-phenylethanamine→4-nitrophenyl (thiazol-5-ylmethyl) carbonate→thiazol-5-ylmethyl ((2S,3S,5S)-5-amino-3-hydroxy-1,6-diphenylhexan-2-yl)carbamate→(S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoic acid→ethyl 2-chloroacetate→ethyl 2-chloro-3-oxopropanoate→methanethioamide→ethyl thiazole-5-carboxylate→thiazol-5-ylmethanol→4-nitrophenyl carbonochloridate→isobutyramide→2-methylpropanethioamide→1,3-dichloropropan-2-one→methyl L-valinate hydrochloride→1-(2-isopropylthiazol-4-yl)-N-methylmethanamine→RITO-025→(S)-methyl 2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoate
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