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CAS 536760-29-9
3-chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
Codes: APIX-024
Application context (from source-drug indications)
Pulmonary embolismApixabanVenous thrombosisApixabanPaget-Schroetter syndromeApixabanVenous thromboembolismApixabanThrombosisApixabanEmbolismApixaban
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Apixaban | Tier A — Act now | 2028 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
ethyl (Z)-2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate→ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate→4-nitroaniline→5-chloropentanoyl chloride→5-bromopentanoyl chloride→1-(4-nitrophenyl)piperidin-2-one→3,3-dichloro-1-(4-nitrophenyl)piperidin-2-one→3-chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one→ethyl 1-(4-methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate→ethyl 6-(4-aminophenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate→ethyl 6-(4-(5-chloropentanamido)phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate→ethyl 6-(4-(5-bromopentanamido)phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
Intermediates available on this site
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| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Qualified Partner — East China API Works | 3-Chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one Pharmaceutical Intermediates | On request | On request | On request | — |
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