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CAS 5394-63-8
2,2-Dimethyl-6-methyl-1,3-dioxin-4-one2,2,4-Trimethyl-6-keto-1,3-dioxin
Codes: (I)638294-1-a, (I)638294-5-a, (IV)638294-12-a, (I)638294-18-a, Lercanidipine Hydrochloride-037
Application context (from source-drug indications)
Systolic heart failureFinerenoneDiastolic heart failureFinerenoneHeart failureFinerenoneChronic renal impairmentFinerenoneDiabetic nephropathyFinerenoneType 2 diabetesFinerenoneEssential hypertensionValsartan/Lercanidipine HydrochlorideHypertensionLercanidipine Hydrochloride
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Finerenone | Tier C — Watch / trade | 2030 |
| Valsartan/Lercanidipine Hydrochloride | Tier C — Watch / trade | - |
| Lercanidipine Hydrochloride | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2,2-Dimethyl-6-methyl-1,3-dioxin-4-one→1-Cyano-2-hydroxyethane→2-Cyanoethyl 3-oxobutanoate→2-Methoxy-4-cyanobenzaldehyde→2-Cyanoethyl (2Z)-2-[(4-cyano-2-methoxyphenyl)methylene]-3-oxobutanoate→4-Amino-5-methylpyridin-2(1H)-one→2-Cyanoethyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate→(Diethoxymethoxy)ethane→1,1,1-Triethoxyethane→2-Cyanoethyl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid→(±)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide→4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,6-naphthyridine-3-carboxamide
2,2-Dimethyl-6-methyl-1,3-dioxin-4-one→(4-Methylphenyl)methyl 3-oxobutanoate→3-Oxobutyric acid benzyl ester→1,1-Dimethylethyl 3-oxobutanoate→Bicyclo[2.2.1]hept-5-en-2-yl 3-oxobutanoate→2-(4-Nitrophenyl)ethyl 3-oxobutanoate→2-Methoxy-4-cyanobenzaldehyde→(4-Methylphenyl)methyl 2-[(4-cyano-2-methoxyphenyl)methylidene]-3-oxobutanoate→2-[(4-Cyano-2-methoxyphenyl)methylene]-3-oxobutanoic acid phenylmethyl ester→tert-Butyl 2-[(4-cyano-2-methoxyphenyl)methylidene]-3-oxobutanoate→Bicyclo[2.2.1]hept-5-en-2-yl 2-[(4-cyano-2-methoxyphenyl)methylidene]-3-oxobutanoate→2-(4-Nitrophenyl)ethyl 2-[(4-cyano-2-methoxyphenyl)methylidene]-3-oxobutanoate→4-Amino-5-methylpyridin-2(1H)-one→(4-Methylphenyl)methyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate→Benzyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate→tert-Butyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate→Bicyclo[2.2.1]hept-5-en-2-yl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate→2-(4-Nitrophenyl)ethyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate→(Diethoxymethoxy)ethane→1,1,1-Triethoxyethane→(4-Methylphenyl)methyl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→Benzyl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→tert-Butyl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→2-(4-Nitrophenyl)ethyl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→(4-Methylphenyl)methyl (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→Benzyl (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→tert-Butyl (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→Bicyclo[2.2.1]hept-5-en-2-yl (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→2-(4-Nitrophenyl)ethyl (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→(4S)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid→Benzyl (4S)-4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate→Bicyclo[2.2.1]hept-5-en-2-yl (4S)-4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate
(S)-2-Amino-3-hydroxypropanoic acid→(S)-Ethyl 2-amino-3-hydroxypropanoate hydrochloride→(S)-Ethyl 2-((tert-butoxycarbonyl)amino)-3-hydroxypropanoate→2,2-Dimethyl-6-methyl-1,3-dioxin-4-one→(2S)-2-[(tert-Butoxycarbonyl)amino]-3-ethoxy-3-oxopropyl 3-oxobutanoate→2-Methoxy-4-cyanobenzaldehyde→(2S)-2-[(tert-Butoxycarbonyl)amino]-3-ethoxy-3-oxopropyl-2-[(4-cyano-2-methoxyphenyl)methylidene]-3-oxobutanoate→4-Amino-5-methylpyridin-2(1H)-one→(2S)-2-[(tert-Butoxycarbonyl)amino]-3-ethoxy-3-oxopropyl 4-(4-cyano-2-methoxyphenyl)-5-hydroxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→(Diethoxymethoxy)ethane→(2S)-2-[(tert-Butoxycarbonyl)amino]-3-ethoxy-3-oxopropyl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→(2S)-2-[(tert-Butoxycarbonyl)amino]-3-ethoxy-3-oxopropyl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,6-naphthyridine-3-carboxylate→(2S)-2-[(tert-Butoxycarbonyl)amino]-3-ethoxy-3-oxopropyl (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate
2,2-Dimethyl-6-methyl-1,3-dioxin-4-one→(4-Nitrophenyl)methyl 3-oxobutanoate→(4-Methoxyphenyl)methyl 3-oxobutanoate→2-Methoxy-4-cyanobenzaldehyde→(4-Nitrophenyl)methyl (2E)-2-[(4-cyano-2-methoxyphenyl)methylidene]-3-oxobutanoate→(4-Methoxyphenyl)methyl (2E)-2-[(4-cyano-2-methoxyphenyl)methylidene]-3-oxobutanoate→4-Amino-5-methylpyridin-2(1H)-one→(4-Nitrophenyl)methyl 4-(4-cyano-2-methoxyphenyl)-5-hydroxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→(4-Methoxyphenyl)methyl 4-(4-cyano-2-methoxyphenyl)-5-hydroxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→(4-Nitrophenyl)methyl (4S)-4-(4-cyano-2-methoxyphenyl)-5-hydroxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→1,1,1-Triethoxyethane→(Diethoxymethoxy)ethane→(4-Nitrophenyl)methyl (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→(4-Methoxyphenyl)methyl (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→(4-Nitrophenyl)methyl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→(4-Methoxyphenyl)methyl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→(4S)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid
1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-ol→2,2,4-Trimethyl-6-keto-1,3-dioxin→3-Oxobutanoyl chloride→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl 3-oxobutanoate→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl (2E)-3-aminobut-2-enoate→(3-Nitrophenyl)methanone→1-Methoxybutane-1,3-dione→(Z)-2-Acetyl-3-(3-nitrophenyl)acrylic acid methyl ester
1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-ol→2,2,4-Trimethyl-6-keto-1,3-dioxin→3-Oxobutanoyl chloride→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl 3-oxobutanoate→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl (2E)-3-aminobut-2-enoate→(3-Nitrophenyl)methanone→1-Methoxybutane-1,3-dione→(Z)-2-Acetyl-3-(3-nitrophenyl)acrylic acid methyl ester
Intermediates available on this site
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| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | 4-Bromo-2-methoxybenzaldehyde Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 4-formyl-3-methoxybenzonitrile Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 4-AMino-5-Methylpyridin-2-ol Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 2-chloro-5-methylpyridin-4-amine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 2-Cyanoethyl 3-oxobutanoate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 2-cyanoethyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate Pharmaceutical Intermediates | On request | On request | On request | — |
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