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CAS 541-88-8
2-chloroacetic anhydrideChloroacetic anhydride
Codes: OMAD-011, NINT-016, DABI-022, Bromfenac Sodium-023
Application context (from source-drug indications)
Skin and skin structure infectionOmadacycline tosylateCommunity-acquired bacterial pneumoniaOmadacycline tosylateBacterial infectionOmadacycline tosylateBacterial pneumoniaOmadacycline tosylateBacterial skin diseaseOmadacycline tosylateSystemic sclerosis-associated interstitial lung diseaseNintedanib EsylateIdiopathic pulmonary fibrosisNintedanib EsylateNon-small cell lung cancerNintedanib EsylatePulmonary fibrosisNintedanib EsylateInterstitial lung diseaseNintedanib EsylateHereditary haemorrhagic telangiectasiaNintedanib EsylateVenous thromboembolismDabigatran Etexilate MesylateEmbolismDabigatran Etexilate MesylateStrokeDabigatran Etexilate MesylateIschaemic strokeDabigatran Etexilate MesylatePulmonary embolismDabigatran Etexilate MesylateVenous thrombosisDabigatran Etexilate MesylateInflammatory diseaseBromfenac SodiumPostoperative painBromfenac Sodium眼睛发炎Bromfenac Sodium眼睛疼痛Bromfenac SodiumDry eye syndromeBromfenac Sodium黄斑水肿Bromfenac Sodium
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Omadacycline tosylate | Tier C — Watch / trade | 2030 |
| Nintedanib Esylate | Tier B — Position early | - |
| Dabigatran Etexilate Mesylate | Tier B — Position early | - |
| Bromfenac Sodium | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2,2-dimethylpropan-1-amine→(4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride→1,3,5-trineopentyl-1,3,5-triazinane→2-chloroacetic anhydride→(2-chloro-N-neopentylacetamido)methyl 2-chloroacetate→(4S,4aS,5aR,12aS)-9-((2-chloro-N-neopentylacetamido)methyl)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-N-(hydroxymethyl)-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide→(4aS,5aR,12aS)-9-((2-chloro-N-neopentylacetamido)methyl)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
methyl 2-oxo-1,3-dihydroindole-6-carboxylate →(trimethoxymethyl)benzene→N-(4-aminophenyl)-2-(4-methylpiperazin-1-yl)acetamide→1-methylpiperazine→4-chloro-3-nitrobenzoic acid→methyl 4-chloro-3-nitrobenzoate→dimethyl malonate→dimethyl 2-(4-(methoxycarbonyl)-2-nitrophenyl)malonate→2-chloroacetic anhydride→methyl 1-(2-chloroacetyl)-2-oxoindoline-6-carboxylate→(Z)-methyl 1-(2-chloroacetyl)-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate→(Z)-methyl 3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate→ethanesulfonic acid→N-methyl-4-nitroaniline→2-chloroacetyl chloride→2-chloro-N-methyl-N-(4-nitrophenyl)acetamide
ethyl 3-(3-amino-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoate→hexyl carbonochloridate→2-chloroacetic anhydride→ethyl 3-(2-(chloromethyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate→hexyl (E)-(amino(4-aminophenyl)methylene)carbamate hydrochloride→4-aminobenzimidamide dihydrochloride
2-Amino-4'-bromobenzophenone→N-[2-(4-Bromobenzoyl)phenyl]acetamide→2-Bromoacetyl bromide→2-Chloroacetyl chloride→Bromoacetic anhydride→Chloroacetic anhydride→N-Acetyl-2-bromo-N-[2-(4-bromobenzoyl)phenyl]acetamide→N-Acetyl-N-[2-(4-bromobenzoyl)phenyl]-2-chloroacetamide→1-Acetyl-7-(4-bromobenzoyl)-1,3-dihydro-2H-indol-2-one
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Qualified Partner — East China API Works | Dabigatran etexilate mesylate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | ethyl N-[3-amino-4-(methylamino)benzoyl]-N-pyridin-2-yl-beta-alaninate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | N-(4-cyanophenyl)-Glycine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 2-Chloro-N-methyl-N-(4-nitrophenyl)acetamide Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | Trimethyl orthobenzoate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin -1-yl)acetamide Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | Methyl 2-oxoindole-6-carboxylate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | (3E)-2,3-Dihydro-3-(methoxyphenylmethylene) -2-oxo-1H-indole-6- carboxylic acid methyl ester Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.