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CAS 5469-69-2
6-chloropyridazin-3-amine
Codes: RELU-010, ENSAR-002, RISD-031
Application context (from source-drug indications)
Prostate cancerRelugolixLeiomyomaRelugolixNon-small cell lung cancerEnsartinib HydrochlorideLung cancerEnsartinib HydrochlorideBrain metastasesEnsartinib HydrochlorideNon-Hodgkin lymphomaEnsartinib HydrochlorideHepatoblastomaEnsartinib HydrochlorideOsteosarcomaEnsartinib HydrochlorideSpinal muscular atrophyRisdiplam
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Relugolix | Tier C — Watch / trade | 2031 |
| Ensartinib Hydrochloride | Tier C — Watch / trade | - |
| Risdiplam | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
ethyl 2-amino-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylate→ethyl 2-((ethoxycarbonyl)amino)-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylate→2-(chloromethyl)-1,3-difluorobenzene→ethyl 2-((2,6-difluorobenzyl)(ethoxycarbonyl)amino)-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylate→ethyl 4-(bromomethyl)-2-((2,6-difluorobenzyl)(ethoxycarbonyl)amino)-5-(4-nitrophenyl)thiophene-3-carboxylate→ethyl 2-((2,6-difluorobenzyl)(ethoxycarbonyl)amino)-4-(((2-methoxyethyl)(methyl)amino)methyl)-5-(4-nitrophenyl)thiophene-3-carboxylate→ethyl 5-(4-aminophenyl)-2-((2,6-difluorobenzyl)(ethoxycarbonyl)amino)-4-(((2-methoxyethyl)(methyl)amino)methyl)thiophene-3-carboxylate→ethyl 2-((2,6-difluorobenzyl)(ethoxycarbonyl)amino)-4-(((2-methoxyethyl)(methyl)amino)methyl)-5-(4-(3-methoxyureido)phenyl)thiophene-3-carboxylate→2-((2,6-difluorobenzyl)(ethoxycarbonyl)amino)-4-(((2-methoxyethyl)(methyl)amino)methyl)-5-(4-(3-methoxyureido)phenyl)thiophene-3-carboxylic acid→6-chloropyridazin-3-amine→1-(4-(1-(2,6-difluorobenzyl)-5-(((2-methoxyethyl)(methyl)amino)methyl)-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-3-methoxyurea→1-chloroethyl carbonochloridate
3,6-dichloropyridazine→6-chloropyridazin-3-amine→4-bromo-6-chloropyridazin-3-amine→1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol→(R)-6-chloro-4-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridazin-3-amine→ENSAR-006→ENSAR-007→ENSAR-008→methyl 4-aminobenzoate→ENSAR-010→ENSAR-011→(2R,6S)-2,6-dimethylpiperazine→ENSAR-013→1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol
1-aminocyclopropanecarboxylic acid→ethyl 1-aminocyclopropanecarboxylate hydrochloride→2-chloroacetyl chloride→ethyl 1-(2-chloroacetamido)cyclopropanecarboxylate→7-benzyl-4,7-diazaspiro[2.5]octane-5,8-dione→7-benzyl-4,7-diazaspiro[2.5]octane→tert-butyl 7-benzyl-4,7-diazaspiro[2.5]octane-4-carboxylate→oxalic acid→tert-butyl 4,7-diazaspiro[2.5]octane-4-carboxylate hemioxalate→tert-butyl 4,7-diazaspiro[2.5]octane-4-carboxylate→5-bromo-2-chloropyridine→tert-butyl 7-(6-chloropyridin-3-yl)-4,7-diazaspiro[2.5]octane-4-carboxylate→tert-butyl 7-(6-aminopyridin-3-yl)-4,7-diazaspiro[2.5]octane-4-carboxylate→di-tert-butyl malonate→tert-butyl 7-(2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidin-7-yl)-4,7-diazaspiro[2.5]octane-4-carboxylate→tert-butyl 7-(4-oxo-2-(tosyloxy)-4H-pyrido[1,2-a]pyrimidin-7-yl)-4,7-diazaspiro[2.5]octane-4-carboxylate→2,8-dimethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-b]pyridazine→tert-butyl 7-(2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-7-yl)-4,7-diazaspiro[2.5]octane-4-carboxylate→6-chloropyridazin-3-amine→4-bromo-6-chloropyridazin-3-amine→6-chloro-4-methylpyridazin-3-amine→isopropyl acetate→6-chloro-2,8-dimethylimidazo[1,2-b]pyridazine
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Qualified Partner — East China API Works | 2-((2,6-difluorobenzyl)(ethoxycarbonyl)amino)-4-((dimethylamino)methyl)-5-(4-nitrophenyl)thiophene-3-carboxylic acid Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 3-AMINO-6-METHOXYPYRIDAZINE Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | ethyl 2-((2,6-difluorobenzyl)(ethoxycarbonyl)amino)-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 2-AcetaMido-4,5-diMethylthiophene-3-carboxylic acid Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 3-Thiophenecarboxylic acid, 2-[[(2,6-difluorophenyl)methyl](propoxycarbonyl)amino]-4-[(dimethylamino)methyl]-5-(4-nitrophenyl)-, ethyl ester Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 3-Thiophenecarboxylic acid,5-(4-aminophenyl)-2-[[(2,6-difluorophenyl)methyl](ethoxycarbonyl)amino]-4-[(dimethylamino)methyl]-,ethylester, hydrochloride (1:2) Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 2-[(2,6-Difluorobenzyl)ethoxycarbonylamino]-4-((dimethylamino)methyl)-5-(4-nitrophenyl)thiophene-3-carboxylic acid ethyl ester Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 7-fluoro-2-hydroxy-4H-pyrido[1,2-a]pyrimidin-4-one Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 4-Boc-4,7-diazaspiro[2.5]octane Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 2,8-Dimethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-b]pyridazine Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.