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CAS 552-89-6

2-Nitrobenzaldehydeo-Nitrobenzaldehyde2-nitrobenzaldehyde

Codes: Ambroxol- 005, Vazegepant-005

Application context (from source-drug indications)

Chronic bronchitisRoxithromycin/Ambroxol HydrochlorideBronchitisRoxithromycin/Ambroxol HydrochlorideRespiratory tract infectionRoxithromycin/Ambroxol HydrochloridePneumoniaRoxithromycin/Ambroxol HydrochlorideTracheitisRoxithromycin/Ambroxol HydrochlorideBacterial infectionRoxithromycin/Ambroxol HydrochlorideAnaesthesiaAmbroxol HydrochloridePharyngitisAmbroxol HydrochlorideRespiratory diseaseAmbroxol HydrochlorideBronchitisAmbroxol HydrochlorideParkinson's diseaseAmbroxol HydrochlorideParkinsonismAmbroxol HydrochlorideMigraineZavegepantMigraine without auraZavegepant有先兆的偏头痛ZavegepantCluster headacheZavegepantAsthmaZavegepantCOVID-19Zavegepant

Source drugs (routes using this intermediate)

DrugTierExpiry
Roxithromycin/Ambroxol HydrochlorideTier C — Watch / trade-
Ambroxol HydrochlorideTier C — Watch / trade-
ZavegepantTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Roxithromycin/Ambroxol HydrochlorideOptimised routesteps: 5total yield: 14.7g(Ambroxol)
trans-4-Aminocyclohexanol→2,4-Dihydro-1H-3,1-benzoxazine-2,4-dione→trans-2-Amino-N-(4-hydroxycyclohexyl)benzamide→trans-4-(2-Aminobenzylamino)cyclohexanol→2-Nitrobenzaldehyde→trans-4-(2-Nitrophenylmethyleneamino)cyclohexanol
Roxithromycin/Ambroxol HydrochlorideOptimised routesteps: 5total yield: 35.12g(Ambroxol)
3,5-Dibromo-2-nitrobenzaldehyde→trans-4-(2-Nitro-3,5-dibromobenzylideneamino)cyclohexanol→(2-Amino-3,5-dibromophenyl)methyl 1H-imidazole-1-carboxylate→o-Nitrobenzaldehyde→trans-4-Aminocyclohexanol→2-Amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl)benzylamine
Roxithromycin/Ambroxol HydrochlorideOptimised routesteps: 4total yield: 14g(Ambroxol- 005)
o-Nitrotoluene→2-Nitrobenzyl bromide→(2-Nitrophenyl)methanol→[4-(Carboxymethylidene)-2,2,6,6-tetramethylpiperidin-1-yl]oxidanyl→o-Nitrobenzaldehyde
Ambroxol HydrochlorideOptimised routesteps: 5total yield: 14.7g(Ambroxol)
trans-4-Aminocyclohexanol→2,4-Dihydro-1H-3,1-benzoxazine-2,4-dione→trans-2-Amino-N-(4-hydroxycyclohexyl)benzamide→trans-4-(2-Aminobenzylamino)cyclohexanol→2-Nitrobenzaldehyde→trans-4-(2-Nitrophenylmethyleneamino)cyclohexanol
Ambroxol HydrochlorideOptimised routesteps: 5total yield: 35.12g(Ambroxol)
3,5-Dibromo-2-nitrobenzaldehyde→trans-4-(2-Nitro-3,5-dibromobenzylideneamino)cyclohexanol→(2-Amino-3,5-dibromophenyl)methyl 1H-imidazole-1-carboxylate→o-Nitrobenzaldehyde→trans-4-Aminocyclohexanol→2-Amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl)benzylamine
Ambroxol HydrochlorideOptimised routesteps: 4total yield: 14g(Ambroxol- 005)
o-Nitrotoluene→2-Nitrobenzyl bromide→(2-Nitrophenyl)methanol→[4-(Carboxymethylidene)-2,2,6,6-tetramethylpiperidin-1-yl]oxidanyl→o-Nitrobenzaldehyde
ZavegepantRoute 1steps: 14total yield: /
tert-butyl 4-oxopiperidine-1-carboxylate→methyl 2-(dimethoxyphosphoryl)acetate→tert-butyl 4-(2-methoxy-2-oxoethylidene)piperidine-1-carboxylate→tert-butyl 4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate→2-nitrobenzaldehyde→tert-butyl 4-(1-hydroxy-3-methoxy-1-(2-nitrophenyl)-3-oxopropan-2-yl)piperidine-1-carboxylate→tert-butyl 4-(4-hydroxy-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)piperidine-1-carboxylate→3-(piperidin-4-yl)quinolin-2(1H)-one hydrochloride→2,6-dimethylaniline→4-iodo-2,6-dimethylaniline hydrochloride→methyl ((benzyloxy)carbonyl)-L-serinate→methyl 2-(((benzyloxy)carbonyl)amino)acrylate→methyl (Z)-3-(4-amino-3,5-dimethylphenyl)-2-(((benzyloxy)carbonyl)amino)acrylate→methyl (R)-3-(4-amino-3,5-dimethylphenyl)-2-(((benzyloxy)carbonyl)amino)propanoate→methyl (R)-2-(((benzyloxy)carbonyl)amino)-3-(7-methyl-1H-indazol-5-yl)propanoate→methyl (R)-2-amino-3-(7-methyl-1H-indazol-5-yl)propanoate→methyl (R)-3-(7-methyl-1H-indazol-5-yl)-2-(4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamido)propanoate→(R)-3-(7-methyl-1H-indazol-5-yl)-2-(4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamido)propanoic acid→1-(1-methylpiperidin-4-yl)piperazine

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

SupplierProductPrice bandMOQLead timeQualificationsAction
Qualified Partner — East China API Works(R)-METHYL 2-(((BENZYLOXY)CARBONYL)AMINO)-3-(7-METHYL-1H-INDAZOL-5-YL)PROPANOATE
Pharmaceutical Intermediates
On requestOn requestOn request
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Unibest Nantong cGMP Site3-(piperidin-4-yl)quinolin-2(1h)-one hydrochloride
Pharmaceutical Intermediates
On requestOn requestOn request
—
Unibest Taizhou GMP-like Site3-(piperidin-4-yl)quinolin-2(1h)-one
Pharmaceutical Intermediates
On requestOn requestOn request
—
Qualified Partner — East China API Works1-(1-Methyl-4-piperidinyl)piperazine
Pharmaceutical Intermediates
On requestOn requestOn request
—
Unibest Nantong cGMP Sitemethyl (2R)-2-amino-3-(7-methyl-1H-indazol-5-yl)propanoate dihydrochloride
Pharmaceutical Intermediates
On requestOn requestOn request
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Unibest Taizhou GMP-like Site1H-Indazole-5-propanoic acid,α-amino-7-methyl-,methyl ester, (αR)-
Pharmaceutical Intermediates
On requestOn requestOn request
—
Qualified Partner — East China API Works1-(1-METHYLPIPERIDIN-4-YL)PIPERAZINE 3HCL
Pharmaceutical Intermediates
On requestOn requestOn request
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This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.