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CAS 553-90-2

dimethyl oxalate

Codes: ACLI-001, ASEN-027

Application context (from source-drug indications)

Chronic obstructive pulmonary diseaseAclidinium Bromide/Formoterol Fumarate DihydrateSchizophreniaAsenapine MaleateManiaAsenapine MaleateBipolar I disorderAsenapine MaleateStutteringAsenapine MaleateParanoid schizophreniaAsenapine MaleateDisorganised schizophreniaAsenapine MaleateChronic obstructive pulmonary diseaseAclidinium Bromide

Source drugs (routes using this intermediate)

DrugTierExpiry
Aclidinium Bromide/Formoterol Fumarate DihydrateTier C — Watch / trade-
Asenapine MaleateTier C — Watch / trade-
Aclidinium BromideTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Aclidinium Bromide/Formoterol Fumarate DihydrateOriginator routesteps: 3total yield: 7.2 g
dimethyl oxalate→2-bromothiophene→methyl 2-hydroxy-2,2-di(thiophen-2-yl)acetate→(R)-quinuclidin-3-ol→(1S,3R,4S)-quinuclidin-3-yl 2-hydroxy-2,2-di(thiophen-2-yl)acetate→(3-bromopropoxy)benzene
Asenapine MaleateOptimised routesteps: 7total yield: 60 mg
methyl 2-(5-chloro-2-phenoxyphenyl)acetate→dimethyl oxalate→dimethyl 2-(5-chloro-2-phenoxyphenyl)-3-oxosuccinate→5-chlorodibenzo[b,f]furo[3,4-d]oxepine-1,3-dione→dimethyl 2-chlorodibenzo[b,f]oxepine-10,11-dicarboxylate→dimethyl (10S,11S)-2-chloro-10,11-dihydrodibenzo[b,f]oxepine-10,11-dicarboxylate→((10S,11S)-2-chloro-10,11-dihydrodibenzo[b,f]oxepine-10,11-diyl)dimethanol→((10S,11S)-2-chloro-10,11-dihydrodibenzo[b,f]oxepine-10,11-diyl)bis(methylene) dimethanesulfonate
Aclidinium BromideOriginator routesteps: 3total yield: 7.2 g
dimethyl oxalate→2-bromothiophene→methyl 2-hydroxy-2,2-di(thiophen-2-yl)acetate→(R)-quinuclidin-3-ol→(1S,3R,4S)-quinuclidin-3-yl 2-hydroxy-2,2-di(thiophen-2-yl)acetate→(3-bromopropoxy)benzene

Intermediates available on this site

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This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.