CAS 55676-22-7

1-(6-Chloropyridin-3-yl)ethanone1-(6-chloropyridin-3-yl)ethanone

Codes: (XXXII)1024528-1-c, PERAM-023

Application context (from source-drug indications)

Non-small cell lung cancerPralsetinibThyroid cancerPralsetinibMedullary thyroid cancerPralsetinibTonic-clonic seizurePerampanel HydratePartial-onset seizurePerampanel HydrateEpilepsyPerampanel HydrateSeizurePerampanel Hydrate

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Pralsetinib	Tier C — Watch / trade	2031
Perampanel Hydrate	Tier C — Watch / trade	2028

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

PralsetinibOptimised routesteps: 7total yield: /

1-[6-(4-Fluoro-1H-pyrazol-1-yl)pyridin-3-yl]ethan-1-one→4-Fluoro-1H-pyrazole→2,2,3,3-Tetrafluoropropan-1-ol→4-(2,2,3,3-Tetrafluoropropyl)morpholine→4-Methyl-4-(2,2,3,3-tetrafluoropropyl)morpholin-4-ium mesylate→1,2-Diazole→4-Methyl-4-[(1Z)-2,3,3-trifluoroprop-1-en-1-yl]morpholin-4-ium methanesulfonate→(2Z)-2-Fluoro-3-(morpholin-4-yl)prop-2-enal→Hydrazine dihydrochloride→4-Fluoro-1H-pyrazole hydrogen chloride→5-Bromo-2-chloropyridine→Acetic acid acetic anhydride→1-(6-Chloropyridin-3-yl)ethanone

Perampanel HydrateOptimised routesteps: 5total yield: 62.8 g

5-acetyl-1-phenylpyridin-2(1H)-one→5-acetyl-3-bromo-1-phenylpyridin-2(1H)-one→2-(1,3,2-dioxaborolan-2-yl)benzonitrile→2-(5-acetyl-2-oxo-1-phenyl-1,2-dihydropyridin-3-yl)benzonitrile→(E)-3-(dimethylamino)acrylaldehyde→phenylboronic acid→1-(6-chloropyridin-3-yl)ethanone→5-acetylpyridin-2(1H)-one

Intermediates available on this site

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