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CAS 56-06-4
2,4-Diamino-6-hydroxypyrimidine2,6-diaminopyrimidin-4(3H)-one
Codes: Folic Acid-059, PEME-015
Application context (from source-drug indications)
Essential hypertensionEnalapril Maleate/Folic AcidMegaloblastic anaemiaFolic AcidFolate deficiencyFolic AcidNeural tube defectFolic AcidAnaemiaFolic AcidHot flushesFolic AcidHyperhomocysteinaemiaFolic AcidNon-small cell lung cancerPemetrexed Disodium Hydrate间皮组织肿瘤Pemetrexed Disodium Hydrate胸膜孤立性纤维瘤Pemetrexed Disodium HydrateBladder cancerPemetrexed Disodium HydrateUrothelial carcinomaPemetrexed Disodium HydrateSolid tumourPemetrexed Disodium Hydrate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Enalapril Maleate/Folic Acid | Tier C — Watch / trade | - |
| Folic Acid | Tier C — Watch / trade | - |
| Pemetrexed Disodium Hydrate | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(Methoxycarbonyl)acetonitrile→Guanidine sulfate→2,4-Diamino-6-hydroxypyrimidine→2,4-Diamino-6-hydroxy-5-nitrosopyrimidine→2,5,6-Triaminopyrimidin-4-ol→Sulfuric acid 2,5,6-triaminopyrimidin-4(1H)-one→2,5,6-Triaminopyrimidin-4-ol dihydrobromide→2,5,6-Triaminopyrimidin-4-one dihydrochloride→3-Bromo-2-oxopropanal oxime→1-Chloro-3-(hydroxyimino)propan-2-one→2-Amino-6-(bromomethyl)-4-pteridinol→2-Amino-6-(chloromethyl)-4-pteridinol→N-(4-Aminobenzoyl)-L-glutamic acid
(Methoxycarbonyl)acetonitrile→Guanidine sulfate→2,4-Diamino-6-hydroxypyrimidine→2,4-Diamino-6-hydroxy-5-nitrosopyrimidine→2,5,6-Triaminopyrimidin-4-ol→Sulfuric acid 2,5,6-triaminopyrimidin-4(1H)-one→2,5,6-Triaminopyrimidin-4-ol dihydrobromide→2,5,6-Triaminopyrimidin-4-one dihydrochloride→3-Bromo-2-oxopropanal oxime→1-Chloro-3-(hydroxyimino)propan-2-one→2-Amino-6-(bromomethyl)-4-pteridinol→2-Amino-6-(chloromethyl)-4-pteridinol→N-(4-Aminobenzoyl)-L-glutamic acid
methyl 4-bromobenzoate→but-3-yn-1-ol→methyl 4-(4-hydroxybut-1-yn-1-yl)benzoate→methyl 4-(4-hydroxybutyl)benzoate→methyl 4-(4-oxobutyl)benzoate→methyl 4-(3-bromo-4-oxobutyl)benzoate→2,6-diaminopyrimidin-4(3H)-one→methyl 4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoate→4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoic acid→diethyl (4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoyl)-L-glutamate compound with 4-methylbenzenesulfonamide (1:1)
dimethyl (4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoyl)-L-glutamate→2,6-diaminopyrimidin-4(3H)-one→4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoic acid→ethyl 4-(3-oxopropyl)benzoate→3-ethylbenzo[d]thiazol-3-ium bromide→ethyl 4-(4-hydroxy-3-oxobutyl)benzoate
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