(S)-Aminobutanedioic acid (56-84-8) intermediate

Application context (from source-drug indications)

Cardiac and vascular disordersAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHypertensionAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHyperlipidaemiaAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHeart diseaseAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilEssential hypertensionEnalapril Maleate/Folic AcidHeart failureEnalapril MaleateHypertensionEnalapril MaleateMyocardial infarctionEnalapril MaleateAngina pectorisEnalapril MaleateLeft ventricular dysfunctionEnalapril MaleateSolid tumourEnalapril MaleateLung cancerTalaporfin Sodium脑癌Talaporfin Sodium脉络膜新生血管化Talaporfin Sodium年龄相关性黄斑变性Talaporfin SodiumPort-wine stainTalaporfin SodiumBenign prostatic hyperplasiaTalaporfin Sodium

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Atorvastatin/Hydrochlorothiazide/Aspirin/Enalapril	Tier C — Watch / trade	-
Enalapril Maleate/Folic Acid	Tier C — Watch / trade	-
Enalapril Maleate	Tier C — Watch / trade	-
Talaporfin Sodium	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Atorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilOptimised routesteps: 5total yield: 3.9g(Enalapril-073)

(S)-Aminobutanedioic acid→Dimethyl L-aspartate hydrogen chloride→Dimethyl N-(triphenylmethyl)-L-aspartate→1-(Bromomethyl)benzene→Dimethyl 3-benzyl-N-(triphenylmethyl)-L-aspartate→(3R)-3-Benzyl-L-aspartic acid→2(S)-Amino-4-phenylbutanoic acid

Enalapril Maleate/Folic AcidOptimised routesteps: 5total yield: 3.9g(Enalapril-073)

(S)-Aminobutanedioic acid→Dimethyl L-aspartate hydrogen chloride→Dimethyl N-(triphenylmethyl)-L-aspartate→1-(Bromomethyl)benzene→Dimethyl 3-benzyl-N-(triphenylmethyl)-L-aspartate→(3R)-3-Benzyl-L-aspartic acid→2(S)-Amino-4-phenylbutanoic acid

Enalapril MaleateOptimised routesteps: 5total yield: 3.9g(Enalapril-073)

(S)-Aminobutanedioic acid→Dimethyl L-aspartate hydrogen chloride→Dimethyl N-(triphenylmethyl)-L-aspartate→1-(Bromomethyl)benzene→Dimethyl 3-benzyl-N-(triphenylmethyl)-L-aspartate→(3R)-3-Benzyl-L-aspartic acid→2(S)-Amino-4-phenylbutanoic acid

Talaporfin SodiumOptimised routesteps: 2total yield: /

TALAS-001→21H-9,12-Imino-2,22-metheno-7,4:14,17-dinitrilo-1H-oxepino[4,5-b]azacyclononadecine-16-propanoic acid, 10-ethenyl-5-ethyl-15,16,18,19-tetrahydro-6,11,15,23-tetramethyl-19,21-dioxo-, (15S,16S)-→(S)-2-aminosuccinic acid

Intermediates available on this site

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