CAS 56718-71-9

4-(2-methoxyethyl)phenol

Codes: METOPR-001

Application context (from source-drug indications)

Angina pectorisIvabradine Hydrochloride/Metoprolol TartrateHypertensionMetoprolol SuccinateAngina pectorisMetoprolol SuccinateHeart failureMetoprolol SuccinateHyperthyroidismMetoprolol SuccinateArrhythmiaMetoprolol SuccinateCardiac neurosisMetoprolol Succinate

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Ivabradine Hydrochloride/Metoprolol Tartrate	Tier C — Watch / trade	-
Metoprolol Succinate	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Ivabradine Hydrochloride/Metoprolol TartrateProcess routesteps: 2total yield: 1.2 kg

4-(2-methoxyethyl)phenol→2-(chloromethyl)oxirane→2-((4-(2-methoxyethyl)phenoxy)methyl)oxirane→1-(isopropylamino)-3-(4-(2-methoxyethyl)phenoxy)propan-2-ol

Ivabradine Hydrochloride/Metoprolol TartrateOptimised routesteps: 2total yield: /

4-(2-methoxyethyl)phenol→1-(benzyl(isopropyl)amino)-3-chloropropan-2-ol→1-(benzyl(isopropyl)amino)-3-(4-(2-methoxyethyl)phenoxy)propan-2-ol

Ivabradine Hydrochloride/Metoprolol TartrateOptimised routesteps: 3total yield: /

4-(2-methoxyethyl)phenol→3-chloro-2-hydroxypropanoic acid→2-hydroxy-3-(4-(2-methoxyethyl)phenoxy)propanoic acid→2-hydroxy-N-isopropyl-3-(4-(2-methoxyethyl)phenoxy)propanamide

Ivabradine Hydrochloride/Metoprolol TartrateOptimised routesteps: 2total yield: 0.62 g

4-(2-methoxyethyl)phenol→3-bromoprop-1-ene→1-(allyloxy)-4-(2-methoxyethyl)benzene

Metoprolol SuccinateProcess routesteps: 2total yield: 1.2 kg

4-(2-methoxyethyl)phenol→2-(chloromethyl)oxirane→2-((4-(2-methoxyethyl)phenoxy)methyl)oxirane→1-(isopropylamino)-3-(4-(2-methoxyethyl)phenoxy)propan-2-ol

Metoprolol SuccinateOptimised routesteps: 2total yield: /

4-(2-methoxyethyl)phenol→1-(benzyl(isopropyl)amino)-3-chloropropan-2-ol→1-(benzyl(isopropyl)amino)-3-(4-(2-methoxyethyl)phenoxy)propan-2-ol

Metoprolol SuccinateOptimised routesteps: 3total yield: /

4-(2-methoxyethyl)phenol→3-chloro-2-hydroxypropanoic acid→2-hydroxy-3-(4-(2-methoxyethyl)phenoxy)propanoic acid→2-hydroxy-N-isopropyl-3-(4-(2-methoxyethyl)phenoxy)propanamide

Metoprolol SuccinateOptimised routesteps: 2total yield: 0.62 g

4-(2-methoxyethyl)phenol→3-bromoprop-1-ene→1-(allyloxy)-4-(2-methoxyethyl)benzene

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