1-(2-Chloroethoxy)-2-ethoxybenzene (56842-04-7) intermediate

Application context (from source-drug indications)

Erectile dysfunctionTadalafil/TamsulosinBenign prostatic hyperplasiaTadalafil/TamsulosinLower urinary tract symptomsSolifenacin Succinate/Tamsulosin HydrochlorideBenign prostatic hyperplasiaSolifenacin Succinate/Tamsulosin HydrochlorideOveractive bladderSolifenacin Succinate/Tamsulosin HydrochlorideDrug-related adverse effects and reactionsSolifenacin Succinate/Tamsulosin HydrochlorideBladder neck obstructionSolifenacin Succinate/Tamsulosin HydrochlorideBenign prostatic hyperplasiaDutasteride/Tamsulosin HydrochlorideBenign prostatic hyperplasiaTamsulosin HydrochlorideUrinary tract infectionTamsulosin HydrochlorideUrinary retentionTamsulosin HydrochlorideInguinal herniaTamsulosin HydrochlorideVoiding dysfunctionTamsulosin HydrochlorideLower urinary tract symptomsTamsulosin Hydrochloride

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Tadalafil/Tamsulosin	Tier C — Watch / trade	-
Solifenacin Succinate/Tamsulosin Hydrochloride	Tier C — Watch / trade	-
Dutasteride/Tamsulosin Hydrochloride	Tier C — Watch / trade	-
Tamsulosin Hydrochloride	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Tadalafil/TamsulosinOptimised routesteps: 3total yield: 20g(Tamsulosin Hydrochloride-065)

1-Hydroxy-2-ethoxybenzene→1,2-Dichloroethane→1-(2-Chloroethoxy)-2-ethoxybenzene→1,3-Dihydro-1,3-dioxoisoindole potassium salt→2-[2-(2-Ethoxyphenoxy)ethyl]-1H-isoindole-1,3(2H)-dione→2-(2-Ethoxyphenoxy)ethylamine

Solifenacin Succinate/Tamsulosin HydrochlorideOptimised routesteps: 3total yield: 20g(Tamsulosin Hydrochloride-065)

1-Hydroxy-2-ethoxybenzene→1,2-Dichloroethane→1-(2-Chloroethoxy)-2-ethoxybenzene→1,3-Dihydro-1,3-dioxoisoindole potassium salt→2-[2-(2-Ethoxyphenoxy)ethyl]-1H-isoindole-1,3(2H)-dione→2-(2-Ethoxyphenoxy)ethylamine

Dutasteride/Tamsulosin HydrochlorideOptimised routesteps: 3total yield: 20g(Tamsulosin Hydrochloride-065)

1-Hydroxy-2-ethoxybenzene→1,2-Dichloroethane→1-(2-Chloroethoxy)-2-ethoxybenzene→1,3-Dihydro-1,3-dioxoisoindole potassium salt→2-[2-(2-Ethoxyphenoxy)ethyl]-1H-isoindole-1,3(2H)-dione→2-(2-Ethoxyphenoxy)ethylamine

Tamsulosin HydrochlorideOptimised routesteps: 3total yield: 20g(Tamsulosin Hydrochloride-065)

1-Hydroxy-2-ethoxybenzene→1,2-Dichloroethane→1-(2-Chloroethoxy)-2-ethoxybenzene→1,3-Dihydro-1,3-dioxoisoindole potassium salt→2-[2-(2-Ethoxyphenoxy)ethyl]-1H-isoindole-1,3(2H)-dione→2-(2-Ethoxyphenoxy)ethylamine

Intermediates available on this site

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