CAS 58045-41-3

methyl (E)-3-(4-formylphenyl)acrylate

Codes: PANO-004

Application context (from source-drug indications)

Multiple myelomaPanobinostat LactateGliomaPanobinostat LactateDiffuse intrinsic pontine gliomaPanobinostat LactateDiffuse midline gliomaPanobinostat LactateMyelodysplastic syndromePanobinostat LactateAcute myeloid leukaemiaPanobinostat Lactate

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Panobinostat Lactate	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Panobinostat LactateOriginator routesteps: 4total yield: /

2-methyl-1H-indole→2-(2-methyl-1H-indol-3-yl)-2-oxoacetamide→2-(2-methyl-1H-indol-3-yl)ethan-1-amine→methyl (E)-3-(4-formylphenyl)acrylate→methyl (E)-3-(4-(((2-(2-methyl-1H-indol-3-yl)ethyl)amino)methyl)phenyl)acrylate

Panobinostat LactateOptimised routesteps: 5total yield: /

2-(2-methyl-1H-indol-3-yl)ethan-1-amine→methyl (E)-3-(4-formylphenyl)acrylate→4-bromobenzaldehyde→methyl acrylate→methyl (E)-3-(4-(((2-(2-methyl-1H-indol-3-yl)ethyl)amino)methyl)phenyl)acrylate hydrochloride→2-hydroxypropanoic acid→phenylhydrazine→5-chloropentan-2-one

Intermediates available on this site

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