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CAS 588-63-6

(3-bromopropoxy)benzene

Codes: ACLI-006

Application context (from source-drug indications)

Chronic obstructive pulmonary diseaseAclidinium Bromide/Formoterol Fumarate DihydrateChronic obstructive pulmonary diseaseAclidinium Bromide

Source drugs (routes using this intermediate)

DrugTierExpiry
Aclidinium Bromide/Formoterol Fumarate DihydrateTier C — Watch / trade-
Aclidinium BromideTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Aclidinium Bromide/Formoterol Fumarate DihydrateOriginator routesteps: 3total yield: 7.2 g
dimethyl oxalate→2-bromothiophene→methyl 2-hydroxy-2,2-di(thiophen-2-yl)acetate→(R)-quinuclidin-3-ol→(1S,3R,4S)-quinuclidin-3-yl 2-hydroxy-2,2-di(thiophen-2-yl)acetate→(3-bromopropoxy)benzene
Aclidinium BromideOriginator routesteps: 3total yield: 7.2 g
dimethyl oxalate→2-bromothiophene→methyl 2-hydroxy-2,2-di(thiophen-2-yl)acetate→(R)-quinuclidin-3-ol→(1S,3R,4S)-quinuclidin-3-yl 2-hydroxy-2,2-di(thiophen-2-yl)acetate→(3-bromopropoxy)benzene

Intermediates available on this site

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