(4-iodophenyl)methanamine hydrochloride (59528-27-7) intermediate

Application context (from source-drug indications)

HypertensionAtorvastatin Calcium Hydrate/IrbesartanHyperlipidaemiaAtorvastatin Calcium Hydrate/IrbesartanHypertensionIrbesartan/TrichlormethiazideOesophageal diseaseIrbesartanHypertensionIrbesartanDiabetic nephropathyIrbesartanHypercholesterolaemiaIrbesartanAlbuminuriaIrbesartanType 2 diabetesIrbesartan

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Atorvastatin Calcium Hydrate/Irbesartan	Tier C — Watch / trade	-
Irbesartan/Trichlormethiazide	Tier C — Watch / trade	-
Irbesartan	Tier B — Position early	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Atorvastatin Calcium Hydrate/IrbesartanOptimised routesteps: 3total yield: 1.83 g

1-pentanamidocyclopentane-1-carboxylic acid→(4-iodophenyl)methanamine hydrochloride→N-(4-iodobenzyl)-1-pentanamidocyclopentane-1-carboxamide→2-butyl-3-(4-iodobenzyl)-1,3-diazaspiro[4.4]non-1-en-4-one→(2-(1H-tetrazol-5-yl)phenyl)boronic acid

Irbesartan/TrichlormethiazideOptimised routesteps: 3total yield: 1.83 g

1-pentanamidocyclopentane-1-carboxylic acid→(4-iodophenyl)methanamine hydrochloride→N-(4-iodobenzyl)-1-pentanamidocyclopentane-1-carboxamide→2-butyl-3-(4-iodobenzyl)-1,3-diazaspiro[4.4]non-1-en-4-one→(2-(1H-tetrazol-5-yl)phenyl)boronic acid

IrbesartanOptimised routesteps: 3total yield: 1.83 g

1-pentanamidocyclopentane-1-carboxylic acid→(4-iodophenyl)methanamine hydrochloride→N-(4-iodobenzyl)-1-pentanamidocyclopentane-1-carboxamide→2-butyl-3-(4-iodobenzyl)-1,3-diazaspiro[4.4]non-1-en-4-one→(2-(1H-tetrazol-5-yl)phenyl)boronic acid

Intermediates available on this site

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