4-chloro-2,3-dimethylpyridine 1-oxide (59886-90-7) intermediate

Application context (from source-drug indications)

Duodenal ulcerRabeprazole Sodium/Metronidazole/AmoxicillinImmune thrombocytopenic purpuraRabeprazole Sodium/Metronidazole/AmoxicillinGastric ulcerRabeprazole Sodium/Metronidazole/AmoxicillinGastritisRabeprazole Sodium/Metronidazole/AmoxicillinHelicobacter pylori infectionRabeprazole Sodium/Metronidazole/AmoxicillinMarginal zone B-cell lymphomaClarithromycin/Rabeprazole Sodium/AmoxicillinDuodenal ulcerClarithromycin/Rabeprazole Sodium/AmoxicillinImmune thrombocytopenic purpuraClarithromycin/Rabeprazole Sodium/AmoxicillinGastric ulcerClarithromycin/Rabeprazole Sodium/AmoxicillinGastritisClarithromycin/Rabeprazole Sodium/AmoxicillinHelicobacter pylori infectionClarithromycin/Rabeprazole Sodium/AmoxicillinGastro-oesophageal reflux diseaseRabeprazole SodiumPeptic oesophagitisRabeprazole SodiumDuodenal ulcerRabeprazole SodiumGastric ulcerRabeprazole SodiumZollinger-Ellison syndromeRabeprazole SodiumHeartburnRabeprazole Sodium

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Rabeprazole Sodium/Metronidazole/Amoxicillin	Tier C — Watch / trade	-
Clarithromycin/Rabeprazole Sodium/Amoxicillin	Tier C — Watch / trade	-
Rabeprazole Sodium	Tier B — Position early	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Rabeprazole Sodium/Metronidazole/AmoxicillinOriginator routesteps: 4total yield: 530 mg

3-methoxypropan-1-ol→4-chloro-2,3-dimethylpyridine 1-oxide→4-(3-methoxypropoxy)-2,3-dimethylpyridine 1-oxide→2-(chloromethyl)-4-(3-methoxypropoxy)-3-methylpyridine→1H-benzo[d]imidazole-2-thiol→2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole

Clarithromycin/Rabeprazole Sodium/AmoxicillinOriginator routesteps: 4total yield: 530 mg

3-methoxypropan-1-ol→4-chloro-2,3-dimethylpyridine 1-oxide→4-(3-methoxypropoxy)-2,3-dimethylpyridine 1-oxide→2-(chloromethyl)-4-(3-methoxypropoxy)-3-methylpyridine→1H-benzo[d]imidazole-2-thiol→2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole

Rabeprazole SodiumOriginator routesteps: 4total yield: 530 mg

3-methoxypropan-1-ol→4-chloro-2,3-dimethylpyridine 1-oxide→4-(3-methoxypropoxy)-2,3-dimethylpyridine 1-oxide→2-(chloromethyl)-4-(3-methoxypropoxy)-3-methylpyridine→1H-benzo[d]imidazole-2-thiol→2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole

Intermediates available on this site

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