CAS 60230-36-6

2,6-difluorobenzene-1-sulfonyl chloride

Codes: DABF-002

Application context (from source-drug indications)

Thyroid cancerDabrafenib MesylateColorectal cancerDabrafenib MesylateGliomaDabrafenib MesylateAnaplastic thyroid cancerDabrafenib MesylateSolid tumourDabrafenib MesylateNon-small cell lung cancerDabrafenib Mesylate

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Dabrafenib Mesylate	Tier B — Position early	2029

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Dabrafenib MesylateOptimised routesteps: 5total yield: 3.58 g

ethyl 3-(3-amino-2-fluorophenyl)-3-oxopropanoate→2,6-difluorobenzene-1-sulfonyl chloride→ethyl 3-(3-(2,6-difluorophenylsulfonamido)-2-fluorophenyl)-3-oxopropanoate→2,2-dimethylpropanethioamide→ethyl 2-(tert-butyl)-4-(3-(2,6-difluorophenylsulfonamido)-2-fluorophenyl)thiazole-5-carboxylate→N-(3-(5-acetyl-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide

Dabrafenib MesylateOriginator routesteps: 6total yield: 2.39 g

2,6-difluorobenzene-1-sulfonyl chloride→2,2-dimethylpropanethioamide→methyl 3-amino-2-fluorobenzoate→methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate→2-chloro-4-methylpyrimidine→N-(3-(2-(2-chloropyrimidin-4-yl)acetyl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide→N-(3-(2-bromo-2-(2-chloropyrimidin-4-yl)acetyl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide→N-(3-(2-(tert-butyl)-5-(2-chloropyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide

Intermediates available on this site

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Supplier	Product	Price band	MOQ	Lead time	Qualifications	Action
Qualified Partner — East China API Works	2,6-Difluorobenzenesulfonyl chloride Pharmaceutical Intermediates	On request	On request	On request	—

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