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CAS 603983-68-2

3-[(1R)-1-Hydroxy-2-iodoethyl]phenol

Codes: Phenylephrine Hydrochloride-017

Application context (from source-drug indications)

Common coldIbuprofen/Phenylephrine HydrochlorideFeverIbuprofen/Phenylephrine HydrochlorideHeadacheIbuprofen/Phenylephrine HydrochlorideMydriasisPhenylephrine HydrochlorideHypotensionPhenylephrine HydrochlorideCycloplegiaPhenylephrine HydrochlorideSupraventricular tachycardiaPhenylephrine HydrochlorideShockPhenylephrine HydrochlorideIschaemic strokePhenylephrine Hydrochloride

Source drugs (routes using this intermediate)

DrugTierExpiry
Ibuprofen/Phenylephrine HydrochlorideTier C — Watch / trade-
Phenylephrine HydrochlorideTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Ibuprofen/Phenylephrine HydrochlorideOptimised routesteps: 9total yield: /
(3-Hydroxyphenyl)formaldehyde→3-(tert-Butyldimethylsilyloxy)benzaldehyde→Methylene(triphenyl)phosphorane→Methyl(triphenyl)phosphonium iodide→tert-Butyl(dimethyl)(3-vinylphenoxy)silane→(1R)-1-(3-[[tert-Butyl(dimethyl)silyl]oxy]phenyl)ethane-1,2-diol→(2R)-2-(3-[[tert-Butyl(dimethyl)silyl]oxy]phenyl)-2-hydroxyethyl 4-methylbenzenesulfonate→(2R)-2-Hydroxy-2-(3-hydroxyphenyl)ethyl 4-methylbenzenesulfonate→3-[(1R)-1-Hydroxy-2-iodoethyl]phenol→Aminomethane→3-[(1R)-1-Hydroxy-2-(methylamino)ethyl]phenol
Phenylephrine HydrochlorideOptimised routesteps: 9total yield: /
(3-Hydroxyphenyl)formaldehyde→3-(tert-Butyldimethylsilyloxy)benzaldehyde→Methylene(triphenyl)phosphorane→Methyl(triphenyl)phosphonium iodide→tert-Butyl(dimethyl)(3-vinylphenoxy)silane→(1R)-1-(3-[[tert-Butyl(dimethyl)silyl]oxy]phenyl)ethane-1,2-diol→(2R)-2-(3-[[tert-Butyl(dimethyl)silyl]oxy]phenyl)-2-hydroxyethyl 4-methylbenzenesulfonate→(2R)-2-Hydroxy-2-(3-hydroxyphenyl)ethyl 4-methylbenzenesulfonate→3-[(1R)-1-Hydroxy-2-iodoethyl]phenol→Aminomethane→3-[(1R)-1-Hydroxy-2-(methylamino)ethyl]phenol

Intermediates available on this site

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This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.