CAS 608-31-1

2,6-Dichloroaniline

Codes: (V)91353-2-a, (I)91353-4-a, (I)91353-5-a, (V)91353-6-a, (I)122568-1-a, (VI)122568-3-a, (III)122568-4-a, (V)122568-5-a

Application context (from source-drug indications)

Back painDiclofenac Sodium/Eperisone HydrochlorideAttention deficit hyperactivity disorderClonidine Hydrochloride (Tris Pharma)HypertensionClonidine Hydrochloride (Tris Pharma)OsteoarthritisDiclofenac SodiumRheumatoid arthritisDiclofenac SodiumAnkylosing spondylitisDiclofenac SodiumCommon bile duct diseaseDiclofenac SodiumDental pulp diseaseDiclofenac SodiumArthritisDiclofenac Sodium

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Diclofenac Sodium/Eperisone Hydrochloride	Tier C — Watch / trade	-
Clonidine Hydrochloride (Tris Pharma)	Tier C — Watch / trade	-
Diclofenac Sodium	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Diclofenac Sodium/Eperisone HydrochlorideOptimised routesteps: 6total yield: /

1-(Chloromethyl)-2-iodobenzene→2-(2-Iodophenyl)[14C]acetonitrile→2-(2-Iodophenyl)[14C]acetic acid→2-(2-Iodophenyl)[14C]acetic acid methyl ester→2,6-Dichloroaniline→2-[2-(2,6-Dichlorophenylamino)phenyl][14C]acetic acid methyl ester→2-[2-(2,6-Dichlorophenylamino)phenyl][14C]acetic acid→2-[2-(2,6-Dichlorophenylamino)phenyl][14C]acetic acid sodium salt

Diclofenac Sodium/Eperisone HydrochlorideOptimised routesteps: 4total yield: /

2,6-Dichloroaniline→2-Phenylacetyl chloride→N-(2,6-Dichlorophenyl)-2-phenylacetamide→N-Chloro-N-(2,6-dichlorophenyl)-2-phenylacetamide→1-(2,6-Dichlorophenyl)-2,3-dihydro-1H-indol-2-one→2-Chloro-N-(2,6-dichlorophenyl)-N-phenylacetamide

Diclofenac Sodium/Eperisone HydrochlorideOptimised routesteps: 2total yield: /

2,6-Dichloroaniline→Methyl (2-bromophenyl)acetate→Methyl (2-chlorophenyl)acetate→2-[2-(2,6-Dichlorophenylamino)phenyl]acetic acid methyl ester

Diclofenac Sodium/Eperisone HydrochlorideOptimised routesteps: 3total yield: /

2-Chlorobenzyl chloride→1-(Bromomethyl)-2-chlorobenzene→Formic acid→(2-Chlorophenyl)acetic acid→1-Chloranyl-2-methylbenzene→2,6-Dichloroaniline→2-[2-(2,6-Dichlorophenylamino)phenyl]acetic acid

Clonidine Hydrochloride (Tris Pharma)Optimised routesteps: 3total yield: /

2,6-Dichloroaniline→(2,6-dichlorophenyl)thiourea→N-[(2,6-Dichlorophenyl)carbamothioyl]benzamide→Methyl N-(2,6-dichlorophenyl)carbamimidothioate hydrogen iodide→1,2-Diaminoethane

Clonidine Hydrochloride (Tris Pharma)Optimised routesteps: 4total yield: /

1-Chloro-2-nitrobenzene→N-(2-chlorophenyl)hydroxylamine→Formic acid→N-(2-Chlorophenyl)-N-hydroxyformamide→2,6-Dichloroaniline→N-(2,6-Dichlorophenyl)formamide→1,2-Diaminoethane

Clonidine Hydrochloride (Tris Pharma)Optimised routesteps: 2total yield: /

2-Mercaptoimidazoline→4,5-Dihydro-1H-imidazole-2-sulfonic acid→2,6-Dichloroaniline

Clonidine Hydrochloride (Tris Pharma)Optimised routesteps: 3total yield: /

2-Mercaptoimidazoline→1,1-Dimethylethyl monobromoacetate→tert-Butyl [(4,5-dihydro-1H-imidazol-2-yl)sulfanyl]acetate hydrogen bromide→Methyl 2-[(2-tert-butoxy-2-oxoethyl)sulfanyl]-4,5-dihydro-1H-imidazole-1-carboxylate→2,6-Dichloroaniline

Diclofenac SodiumOptimised routesteps: 6total yield: /

Diclofenac SodiumOptimised routesteps: 4total yield: /

Diclofenac SodiumOptimised routesteps: 2total yield: /

2,6-Dichloroaniline→Methyl (2-bromophenyl)acetate→Methyl (2-chlorophenyl)acetate→2-[2-(2,6-Dichlorophenylamino)phenyl]acetic acid methyl ester

Diclofenac SodiumOptimised routesteps: 3total yield: /

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