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CAS 610-14-0
2-nitrobenzoyl chloride
Codes: IVAC-017, SIVE-001
Application context (from source-drug indications)
Cystic fibrosisIvacaftorChronic bronchitisIvacaftorChronic obstructive pulmonary diseaseIvacaftorSinusitisIvacaftorAcute lung injurySivelestat Sodium Hydrate全身炎症反应综合征Sivelestat Sodium Hydrate视神经脊髓炎Sivelestat Sodium Hydrate感染性休克Sivelestat Sodium Hydrate血液凝固障碍Sivelestat Sodium HydrateCoronary artery lesionSivelestat Sodium Hydrate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Ivacaftor | Tier B — Position early | - |
| Sivelestat Sodium Hydrate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-nitrobenzoyl chloride→diethyl 2-(2-nitrobenzoyl)malonate→ethyl 3-(2-nitrophenyl)-3-oxopropanoate→5-amino-2,4-di-tert-butylphenyl methyl carbonate→2,4-di-tert-butyl-5-(3-(2-nitrophenyl)-3-oxopropanamido)phenyl methyl carbonate→2,4-di-tert-butyl-5-(3-(dimethylamino)-2-(2-nitrobenzoyl)acrylamido)phenyl methyl carbonate→2,4-di-tert-butyl-5-(4-oxo-1,4-dihydroquinoline-3-carboxamido)phenyl methyl carbonate
2-nitrobenzoyl chloride→benzyl glycinate 4-methylbenzenesulfonate→benzyl (2-nitrobenzoyl)glycinate→benzyl (2-aminobenzoyl)glycinate→4-(chlorosulfonyl)phenyl pivalate→4-(N-(2-((2-(benzyloxy)-2-oxoethyl)carbamoyl)phenyl)sulfamoyl)phenyl pivalate→(2-((4-(pivaloyloxy)phenyl)sulfonamido)benzoyl)glycine→4-hydroxybenzenesulfonic acid→pivaloyl chloride→sodium 4-(pivaloyloxy)benzenesulfonate
Intermediates available on this site
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