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CAS 611-73-4

2-oxo-2-phenylacetic acid2-Oxo-2-phenylacetic acid

Codes: GLYC-022, SOFBR-001, Cefonicid-022

Application context (from source-drug indications)

AsthmaBudesonide/Formoterol fumarate/Glycopyrronium BromideChronic obstructive pulmonary diseaseBudesonide/Formoterol fumarate/Glycopyrronium BromideChronic obstructive pulmonary diseaseIndacaterol Maleate/Glycopyrronium BromideSialorrhoeaGlycopyrronium BromideChronic obstructive pulmonary diseaseGlycopyrronium BromideDuodenal ulcerGlycopyrronium BromideGastric ulcerGlycopyrronium BromideGastritisGlycopyrronium BromideAnaesthesiaGlycopyrronium BromideHyperhidrosisSofpironium BromideBacterial infectionCefonicid Sodium

Source drugs (routes using this intermediate)

DrugTierExpiry
Budesonide/Formoterol fumarate/Glycopyrronium BromideTier B — Position early-
Indacaterol Maleate/Glycopyrronium BromideTier B — Position early-
Glycopyrronium BromideTier C — Watch / trade-
Sofpironium BromideTier C — Watch / trade-
Cefonicid SodiumTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Budesonide/Formoterol fumarate/Glycopyrronium BromideOptimised routesteps: 4total yield: 3.9 g (Glycopyrronium Bromide)
bromocyclopentane→methyl 2-cyclopentyl-2-hydroxy-2-phenylacetate→2-cyclopentyl-2-hydroxy-2-phenylacetic acid→1-methylpyrrolidin-3-ol→1-methylpyrrolidin-3-yl 2-cyclopentyl-2-hydroxy-2-phenylacetate→2-oxo-2-phenylacetic acid
Indacaterol Maleate/Glycopyrronium BromideOptimised routesteps: 4total yield: 3.9 g (Glycopyrronium Bromide)
bromocyclopentane→methyl 2-cyclopentyl-2-hydroxy-2-phenylacetate→2-cyclopentyl-2-hydroxy-2-phenylacetic acid→1-methylpyrrolidin-3-ol→1-methylpyrrolidin-3-yl 2-cyclopentyl-2-hydroxy-2-phenylacetate→2-oxo-2-phenylacetic acid
Glycopyrronium BromideOptimised routesteps: 4total yield: 3.9 g (Glycopyrronium Bromide)
bromocyclopentane→methyl 2-cyclopentyl-2-hydroxy-2-phenylacetate→2-cyclopentyl-2-hydroxy-2-phenylacetic acid→1-methylpyrrolidin-3-ol→1-methylpyrrolidin-3-yl 2-cyclopentyl-2-hydroxy-2-phenylacetate→2-oxo-2-phenylacetic acid
Sofpironium BromideOriginator routesteps: 4total yield: /
2-oxo-2-phenylacetic acid→cyclopentylmagnesium bromide→2-cyclopentyl-2-hydroxy-2-phenylacetic acid→(R)-2-cyclopentyl-2-hydroxy-2-phenylacetic acid→(R)-1-methylpyrrolidin-3-ol→(R)-1-methylpyrrolidin-3-yl (R)-2-cyclopentyl-2-hydroxy-2-phenylacetate→(3R)-3-((R)-2-cyclopentyl-2-hydroxy-2-phenylacetoxy)-1-(2-ethoxy-2-oxoethyl)-1-methylpyrrolidin-1-ium bromide
Cefonicid SodiumOptimised routesteps: 4total yield: 170kg（Cefonicid Sodium）
Oxo(phenyl)acetonitrile→2-Oxo-2-phenylacetic acid→(2R)-Hydroxy(phenyl)acetic acid→(2R)-(Formyloxy)(phenyl)acetic acid→Formic acid 2-chloro-2-oxo-1(R)-phenylethyl ester<-fgf->O-Formyl-D-mandelic acid chloride<-fgf->D-O-Formylmandeolyl chloride

Intermediates available on this site

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