CAS 615-41-8

1-chloro-2-iodobenzene1-Chloro-2-iodobenzene

Codes: ESKE-005, (I)270899-2-a, Levamlodipine Besylate-013

Application context (from source-drug indications)

Major depressive disorderEsketamine HydrochlorideSuicidal ideationEsketamine HydrochlorideDepressive disorderEsketamine HydrochlorideAnaesthesiaEsketamine HydrochlorideTreatment-resistant depressionEsketamine HydrochloridePainEsketamine HydrochlorideHypertensionLevamlodipine BesylateAngina pectorisLevamlodipine BesylateEssential hypertensionLevamlodipine Besylate

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Esketamine Hydrochloride	Tier B — Position early	2029
Levamlodipine Besylate	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Esketamine HydrochlorideOptimised routesteps: 4total yield: 6.60 mg (Esketamine Hydrochloride)

1-chloro-2-iodobenzene→cyclohexanone→2-(2-chlorophenyl)cyclohexan-1-one→di-tert-butyl (E)-diazene-1,2-dicarboxylate→di-tert-butyl (S)-1-(1-(2-chlorophenyl)-2-oxocyclohexyl)hydrazine-1,2-dicarboxylate→(S)-2-amino-2-(2-chlorophenyl)cyclohexan-1-one

Esketamine HydrochlorideOptimised routesteps: 4total yield: /

1-Chloro-2-iodobenzene→4-Cyclohexanone→2-(2-Chlorophenyl)cyclohexanone→(E)-Di-tert-butyl azodiformate→Di-tert-butyl 1-[(1S)-1-(2-chlorophenyl)-2-oxocyclohexyl]hydrazine-1,2-dicarboxylate→(-)-2(S)-Amino-2-(2-chlorophenyl)cyclohexanone→(1S)-2'-Chloro-1-isocyanato-6-methoxy-1,2,3,4-tetrahydro-1,1'-biphenyl→Formaldehyde→(2S)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone

Levamlodipine BesylateOptimised routesteps: 2total yield: 9.98g(Amlodipine (Free))

1-tert-Butyl 3-ethyl 5-methyl 2-([2-[(tert-butoxycarbonyl)amino]ethoxy]methyl)-6-methylpyridine-1,3,5(4H)-tricarboxylate→1-Chloro-2-iodobenzene→2-(2-Chlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane→2-(2-Chlorophenyl)-4,4-dimethyl-1,3,2-dioxaborolane→2-(2-Chlorophenyl)-1,3,2-dioxaborolane→1-tert-Butyl 3-ethyl 5-methyl 2-([2-[(tert-butoxycarbonyl)amino]ethoxy]methyl)-4-(2-chlorophenyl)-6-methylpyridine-1,3,5(4H)-tricarboxylate→(±)-2-(2-Aminoethoxymethyl)-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine

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