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CAS 616225-40-2
(S)-benzyl 2-((S)-((tert-butyldimethylsilyl)oxy)((R)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-4-hydroxy-5-oxo-2,5-dihydrofuran-3-carboxylate
Codes: TETRO-046
Application context (from source-drug indications)
神经痛Tetrodotoxin海洛因依赖TetrodotoxinCancer painTetrodotoxinPainTetrodotoxin中毒Tetrodotoxin
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Tetrodotoxin | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(R)-2-((tert-butyldimethylsilyl)oxy)-2-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)acetaldehyde→(S)-benzyl 2-((S)-((tert-butyldimethylsilyl)oxy)((R)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-4-hydroxy-5-oxo-2,5-dihydrofuran-3-carboxylate→(S)-benzyl 2-((S)-((tert-butyldimethylsilyl)oxy)((R)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-5-oxo-4-(pivaloyloxy)-2,5-dihydrofuran-3-carboxylate→(S)-5-((S)-((tert-butyldimethylsilyl)oxy)((R)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-4-(2-diazoacetyl)-2-oxo-2,5-dihydrofuran-3-yl pivalate→(4'R,7S,7aS)-7-((tert-butyldimethylsilyl)oxy)-2',2'-dimethyl-2,4-dioxo-4,5,7,7a-tetrahydro-2H-spiro[benzofuran-6,4'-[1,3]dioxolan]-3-yl pivalate→(3aS,4R,5aS,8S,8aS,8bS)-2,2,2',2'-tetramethyl-7-oxohexahydro-3aH-spiro[[1,3]dioxolo[4,5-e]benzofuran-4,4'-[1,3]dioxolan]-8-yl pivalate→(S)-2-(dimethylamino)-2-oxo-1-((3aS,4R,7S,7aS)-2,2,2',2'-tetramethyl-6-methylenetetrahydro-3aH-spiro[benzo[d][1,3]dioxole-4,4'-[1,3]dioxolan]-7-yl)ethyl pivalate→(S)-1-((3aS,4S,5R,6R,7S,7aS)-6-allyl-5-hydroxy-2,2,2',2'-tetramethyltetrahydro-3aH-spiro[benzo[d][1,3]dioxole-4,4'-[1,3]dioxolan]-7-yl)-2-(dimethylamino)-2-oxoethyl pivalate→(S)-1-((3aS,4S,5R,6R,7S,7aS)-6-allyl-5-hydroxy-2,2,2',2'-tetramethyltetrahydro-3aH-spiro[benzo[d][1,3]dioxole-4,4'-[1,3]dioxolan]-7-yl)-2-(dimethylamino)-2-oxoethyl pivalate→(3aS,4S,5R,8S,9S,9aS,10R)-10-allyl-2,2,2',2'-tetramethyl-7-oxohexahydrospiro[5,9-methano[1,3]dioxolo[4,5-d]oxocine-4,4'-[1,3]dioxolan]-8-yl pivalate→(3aS,4S,5R,8S,9R,9aS,10R)-10-allyl-8-hydroxy-2,2,2',2'-tetramethyltetrahydrospiro[5,9-methano[1,3]dioxolo[4,5-d]oxocine-4,4'-[1,3]dioxolan]-7(3aH)-one→(3aS,4S,5R,8S,9S,9aS,10R)-10-(2-chloroethyl)-2,2,2',2'-tetramethyl-7-oxohexahydrospiro[5,9-methano[1,3]dioxolo[4,5-d]oxocine-4,4'-[1,3]dioxolan]-8-yl carbamate→(3aS,4'S,6R,7aS,10aS,10bR,11R)-11-(2-chloroethyl)-2',2',9,9-tetramethyldihydro-1H-spiro[6,10b-methano[1,3]dioxolo[4',5':5,6]oxocino[4,3-d]oxazole-7,4'-[1,3]dioxolane]-2,4(3aH,6H)-dione→tert-butyl ((3aS,4S,5R,8S,9S,9aS,10R)-8-hydroxy-2,2,2',2'-tetramethyl-7-oxo-10-vinylhexahydrospiro[5,9-methano[1,3]dioxolo[4,5-d]oxocine-4,4'-[1,3]dioxolan]-9-yl)carbamate→(3aS,4S,5R,8S,9S,9aS,10R)-9-amino-8-hydroxy-2,2,2',2'-tetramethyl-10-vinyltetrahydrospiro[5,9-methano[1,3]dioxolo[4,5-d]oxocine-4,4'-[1,3]dioxolan]-7(3aH)-one
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