4-Iodobenzoic acid (619-58-9) intermediate

Application context (from source-drug indications)

AnaesthesiaOxymetazoline Hydrochloride/Tetracaine HydrochloridePeriapical periodontitisOxymetazoline Hydrochloride/Tetracaine HydrochlorideDental cariesOxymetazoline Hydrochloride/Tetracaine HydrochlorideCandidiasisAnidulafunginCandidaemiaAnidulafunginFungal infectionAnidulafunginPeritonitisAnidulafunginAbscessAnidulafunginRespiratory tract infectionAnidulafunginAnaesthesiaTetracaine HydrochlorideRetinitis pigmentosaTetracaine HydrochloridePainTetracaine Hydrochloride

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Oxymetazoline Hydrochloride/Tetracaine Hydrochloride	Tier C — Watch / trade	-
Anidulafungin	Tier C — Watch / trade	-
Tetracaine Hydrochloride	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Oxymetazoline Hydrochloride/Tetracaine HydrochlorideOptimised routesteps: 10total yield: /

4-Aminobenzoic acid sodium salt→4-(Butylamino)benzoic acid→p-Chlorobenzoic acid→4-Bromobenzoic acid→4-Iodobenzoic acid→Butylamine→4-(Butylamino)benzoic acid ethyl ester→2-(Dimethylamino)ethanol hydrochloride→2-Chloroethanol→4-(Butylamino)benzoic acid 2-chloroethyl ester→N-Methylmethanamine→n-Butyl bromide→N,N-Dimethylaminoethanol→4-Aminobenzoic acid 2-(dimethylamino)ethyl ester→4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester

AnidulafunginRoute 7steps: 1total yield: 550g(ANID-004)

4-Iodobenzoic acid→Cyclic bis(tetramethylethylene) ester p-Benzenediboronic acid→1-Iodo-4-(pentyloxy)benzene→4''-(Pentyloxy)-p-terphenyl-4-carboxylic acid

Tetracaine HydrochlorideOptimised routesteps: 10total yield: /

4-Aminobenzoic acid sodium salt→4-(Butylamino)benzoic acid→p-Chlorobenzoic acid→4-Bromobenzoic acid→4-Iodobenzoic acid→Butylamine→4-(Butylamino)benzoic acid ethyl ester→2-(Dimethylamino)ethanol hydrochloride→2-Chloroethanol→4-(Butylamino)benzoic acid 2-chloroethyl ester→N-Methylmethanamine→n-Butyl bromide→N,N-Dimethylaminoethanol→4-Aminobenzoic acid 2-(dimethylamino)ethyl ester→4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications	Action
Qualified Partner — East China API Works	4-(4'-Pentoxy-4-biphenylyl)benzoic acid Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Nantong cGMP Site	1-(Diphenylmethyl)-3-hydroxyazetidine Pharmaceutical Intermediates	On request	On request	On request	—