CAS 619-67-0

4-hydrazinylbenzoic acid

Codes: DEFE-004, DEFE-010

Application context (from source-drug indications)

ThalassaemiaDeferasiroxIron overloadDeferasiroxBeta thalassaemiaDeferasiroxHaematopoietic stem cell transplantationDeferasiroxMyelodysplastic syndromeDeferasiroxAnaemiaDeferasirox

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Deferasirox	Tier B — Position early	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

DeferasiroxOriginator routesteps: 2total yield: /

2-hydroxybenzoyl chloride→2-hydroxybenzamide→2-(2-hydroxyphenyl)-4H-benzo[e][1,3]oxazin-4-one→4-hydrazinylbenzoic acid

DeferasiroxOptimised routesteps: 4total yield: 22.8 g

2-(benzyloxy)benzonitrile→methyl 2-(benzyloxy)benzimidate hydrochloride→methyl 2-(benzyloxy)benzimidate→2-hydroxybenzoyl chloride→2-(2-(benzyloxy)phenyl)-4H-benzo[e][1,3]oxazin-4-one→4-hydrazinylbenzoic acid

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