CAS 62-53-3

Aminobenzeneaniline

Codes: (V)819703-2-a, PERAM-031, SELT-005, Atorvastatin-049, IVAC-001, FENT-004, (I)91353-9-a, (I)91353-11-a, (XXVII)700647-1-c, NELF-013

Application context (from source-drug indications)

Gastrointestinal stromal tumourRipretinibTonic-clonic seizurePerampanel HydratePartial-onset seizurePerampanel HydrateEpilepsyPerampanel HydrateSeizurePerampanel HydratePlexiform neurofibromaSelumetinib sulfateNeurofibromatosis type ISelumetinib sulfateCardiac and vascular disordersAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHypertensionAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHyperlipidaemiaAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHeart diseaseAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilCystic fibrosisIvacaftorChronic bronchitisIvacaftorChronic obstructive pulmonary diseaseIvacaftorSinusitisIvacaftorPainBupivacaine Hydrochloride/Fentanyl CitrateBack painDiclofenac Sodium/Eperisone HydrochlorideHyperlipidaemiaAtorvastatin strontiumSubarachnoid haemorrhageAtorvastatin strontiumHypertensionAtorvastatin strontiumPainFentanylDisease of prematurityFentanylPostoperative painFentanylCancer painFentanylSolid tumourFentanylSurgical painFentanylOsteoarthritisDiclofenac SodiumRheumatoid arthritisDiclofenac SodiumAnkylosing spondylitisDiclofenac SodiumCommon bile duct diseaseDiclofenac SodiumDental pulp diseaseDiclofenac SodiumArthritisDiclofenac Sodium蠕形螨性睑缘炎Lotilaner螨虫感染Lotilaner莱姆病LotilanerRosaceaLotilaner睑板腺功能障碍LotilanerHIV infectionNelfinavir MesylateMyelofibrosisNelfinavir Mesylate子宫颈功能不全Nelfinavir MesylateSystemic lupus erythematosusNelfinavir MesylateNon-small cell lung cancerNelfinavir Mesylate巨细胞病毒性视网膜炎Nelfinavir Mesylate

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Ripretinib	Tier C — Watch / trade	2032
Perampanel Hydrate	Tier C — Watch / trade	2028
Selumetinib sulfate	Tier C — Watch / trade	2032
Atorvastatin/Hydrochlorothiazide/Aspirin/Enalapril	Tier C — Watch / trade	-
Ivacaftor	Tier B — Position early	-
Bupivacaine Hydrochloride/Fentanyl Citrate	Tier C — Watch / trade	-
Diclofenac Sodium/Eperisone Hydrochloride	Tier C — Watch / trade	-
Atorvastatin strontium	Tier C — Watch / trade	-
Fentanyl	Tier C — Watch / trade	-
Diclofenac Sodium	Tier C — Watch / trade	-
Lotilaner	Tier C — Watch / trade	-
Nelfinavir Mesylate	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

RipretinibOptimised routesteps: 5total yield: /

Methyl (2-bromo-4-fluoro-5-nitrophenyl)acetate→6-Chloro-4-nitropyridine-3-carbaldehyde→Methyl (2Z)-2-(2-bromo-4-fluoro-5-nitrophenyl)-3-(6-chloro-4-nitropyridin-3-yl)prop-2-enoate→3-(5-Amino-2-bromo-4-fluorophenyl)-7-chloro-1,6-naphthyridin-2(1H)-one→Aminobenzene→1,1,1-Trichloromethanol 1,1'-carbonate→N-[4-Bromo-5-(7-chloro-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl]-N'-phenylurea→1-Iodoethane→N-[4-Bromo-5-(7-chloro-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl]-N'-phenylurea→Aminomethane

Perampanel HydrateOptimised routesteps: 3total yield: 17.7 g

2-(2-cyanophenyl)acetic acid→aniline→2-(2-cyanophenyl)-N-phenylacetamide→PERAM-033→2-(pyridin-2-yl)acetic acid hydrochloride

Selumetinib sulfateOriginator routesteps: 11total yield: 2.11 g

2,3,4-trifluorobenzoic acid→2,3,4-trifluoro-5-nitrobenzoic acid→4-amino-2,3-difluoro-5-nitrobenzoic acid→methyl 4-amino-2,3-difluoro-5-nitrobenzoate→aniline→SELT-006→SELT-007→SELT-008→SELT-009→SELT-010→SELT-011→methyl 2-((2-fluoro-4-iodophenyl)amino)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylate→SELT-013

Atorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilOptimised routesteps: 7total yield: /

4-Methyl-3-oxopentanoic acid methyl ester→4-Methyl-3-oxopentanoic acid 4-methoxybenzyl ester→Benzaldehyde→2-Benzylidene-4-methyl-3-oxopentanoic acid 4-methoxybenzyl ester→1-[3(R)-[tert-Butyl(dimethyl)silyloxy]-5-hydroxypentyl]-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid→(4-Fluorophenyl)methanone→2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid 4-methoxybenzyl ester→5-Amino-3(R)-[tert-butyl(dimethyl)silyloxy]pentan-1-ol→1-[3(R)-[tert-Butyl(dimethyl)silyloxy]-5-hydroxypentyl]-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid 4-methoxybenzyl ester→Aminobenzene→1-[3(R)-[tert-butyl(dimethyl)silyloxy]-5-hydroxypentyl]-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide→1-[3(R)-[tert-Butyl(dimethyl)silyloxy]-5-oxopentyl]-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide

IvacaftorOriginator routesteps: 8total yield: /

aniline→diethyl 2-(ethoxymethylene)malonate→diethyl 2-((phenylamino)methylene)malonate→ethyl 4-oxo-1,4-dihydroquinoline-3-carboxylate→4-oxo-1,4-dihydroquinoline-3-carboxylic acid→5-amino-2,4-di-tert-butylphenol→2,4-di-tert-butylphenol→2,4-di-tert-butylphenyl methyl carbonate→2,4-di-tert-butyl-5-nitrophenyl methyl carbonate→2,4-di-tert-butyl-5-nitrophenol

Bupivacaine Hydrochloride/Fentanyl CitrateOptimised routesteps: 3total yield: 1.53 g (Fentanyl)

piperidin-4-one hydrochloride hydrate→(2-bromoethyl)benzene→1-phenethylpiperidin-4-one→aniline→1-phenethyl-N-phenylpiperidin-4-amine→(8R,9S,10R,13S,14S,17R)-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl pentanoate

Diclofenac Sodium/Eperisone HydrochlorideOptimised routesteps: 5total yield: /

Aminobenzene→2-Chloranylethanoyl chloride→2-Chloro-N-phenylacetamide→2,6-Dichlorophenol→2,6-Dichloro-N-phenylphenylamine→2-Chloro-N-(2,6-dichlorophenyl)-N-phenylacetamide→1-(2,6-Dichlorophenyl)-2,3-dihydro-1H-indol-2-one

Diclofenac Sodium/Eperisone HydrochlorideOptimised routesteps: 6total yield: /

Aminobenzene→2-Chloroacetic acid→2-Chloro-N-phenylacetamide→2,6-Dichlorophenol→2-(2,6-Dichlorophenoxy)-N-phenylacetamide→N-(2,6-Dichlorophenyl)-2-hydroxy-N-phenylacetamide→2-Chloro-N-(2,6-dichlorophenyl)-N-phenylacetamide→1-(2,6-Dichlorophenyl)-2,3-dihydro-1H-indol-2-one

Atorvastatin strontiumOptimised routesteps: 7total yield: /

FentanylOptimised routesteps: 3total yield: 1.53 g (Fentanyl)

Diclofenac SodiumOptimised routesteps: 5total yield: /

Diclofenac SodiumOptimised routesteps: 6total yield: /

LotilanerOptimised routesteps: 3total yield: /

5-Bromo-1,2,3-trichlorobenzene→4-(Aminosulfonyl)aniline→3,5-Dichlorosulfanilamide→(4-Bromo-2,6-dichlorophenyl)amine→Aminobenzene→p-Bromoaniline

Nelfinavir MesylateOriginator routesteps: 11total yield: 54.00 mg

benzyl ((R)-1-((S)-oxiran-2-yl)-2-(phenylthio)ethyl)carbamate→(3S,4aS,8aS)-N-(tert-butyl)decahydroisoquinoline-3-carboxamide→benzyl ((2R,3R)-4-((3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl)-3-hydroxy-1-(phenylthio)butan-2-yl)carbamate→(3S,4aS,8aS)-2-((2R,3R)-3-amino-2-hydroxy-4-(phenylthio)butyl)-N-(tert-butyl)decahydroisoquinoline-3-carboxamide→3-hydroxy-2-methylbenzoic acid→aniline→3-methoxybenzoyl chloride→3-methoxy-N-phenylbenzamide→3-methoxy-2-methyl-N-phenylbenzamide→(S)-benzyl (2-oxooxetan-3-yl)carbamate→benzenethiol→(R)-2-(((benzyloxy)carbonyl)amino)-3-(phenylthio)propanoic acid→3-methyl-1-nitro-1-nitrosoguanidine→(S)-(2-(((benzyloxy)carbonyl)amino)-3-oxo-2-((phenylthio)methyl)azetidin-1-ium-1-ylidene)amide→(R)-benzyl (4-chloro-3-oxo-1-(phenylthio)butan-2-yl)carbamate→benzyl ((2R,3S)-4-chloro-3-hydroxy-1-(phenylthio)butan-2-yl)carbamate

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications
Unibest Nantong cGMP Site	2-bromo-3-methyl-5-acetylthiophene Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Taizhou GMP-like Site	methyl 5-acetyl-3-methylthiophene-2-carboxylate Pharmaceutical Intermediates	On request	On request	On request	—
Qualified Partner — East China API Works	5-acetyl-3-methyl-2-Thiophenecarboxylic acid Pharmaceutical Intermediates	On request	On request	On request	—

This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.