CAS 623-05-2

4-(hydroxymethyl)phenol4-Hydroxybenzyl alcohol4-(Hydroxymethyl)phenol

Codes: SAFI-015, BAZE-015, Bisoprolol-011

Application context (from source-drug indications)

Parkinson's diseaseSafinamide MesylatePainSafinamide MesylateDrug-induced dyskinesiaSafinamide MesylateHepatic function declineSafinamide MesylateMultiple system atrophySafinamide MesylateRenal impairmentSafinamide MesylateOestrogen deficiency syndromeConjugated Estrogens/Bazedoxifene AcetateOsteoporosisConjugated Estrogens/Bazedoxifene AcetateVasomotor symptomsConjugated Estrogens/Bazedoxifene AcetateNon-invasive ductal carcinomaConjugated Estrogens/Bazedoxifene AcetateAnxietyConjugated Estrogens/Bazedoxifene AcetateMenopausal symptomsConjugated Estrogens/Bazedoxifene AcetateHypertensionAmlodipine Besylate/Bisoprolol FumarateEssential hypertensionAmlodipine Besylate/Bisoprolol FumaratePostmenopausal osteoporosisBazedoxifene AcetateBreast cancerBazedoxifene AcetateOsteoporosisBazedoxifene AcetateMenopausal symptomsBazedoxifene AcetateHypertensionBisoprolol FumarateAngina pectorisBisoprolol FumarateChronic obstructive pulmonary diseaseBisoprolol FumarateCardiac and vascular disordersBisoprolol FumarateAcute coronary syndromeBisoprolol FumarateFastingBisoprolol Fumarate

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Safinamide Mesylate	Tier C — Watch / trade	-
Conjugated Estrogens/Bazedoxifene Acetate	Tier C — Watch / trade	-
Amlodipine Besylate/Bisoprolol Fumarate	Tier C — Watch / trade	-
Bazedoxifene Acetate	Tier C — Watch / trade	-
Bisoprolol Fumarate	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Safinamide MesylateOptimised routesteps: 14total yield: 0.11 g

1-fluoro-3-(iodomethyl)benzene→4-(hydroxymethyl)phenol→(4-((3-fluorobenzyl)oxy)phenyl)methanol→1-fluoro-3-((4-(iodomethyl)phenoxy)methyl)benzene→SAFI-018→SAFI-019→SAFI-020→SAFI-021→2-((benzyloxy)methyl)oxirane→(R)-2-((benzyloxy)methyl)oxirane→(R)-1-(benzyloxy)propan-2-ol→(S)-((2-azidopropoxy)methyl)benzene→(S)-2-aminopropan-1-ol

Conjugated Estrogens/Bazedoxifene AcetateOptimised routesteps: 8total yield: /

5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole→azepane→1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole→4-(hydroxymethyl)phenol→2-chloroacetonitrile→2-(4-(hydroxymethyl)phenoxy)acetonitrile→2-(4-(chloromethyl)phenoxy)acetonitrile→2-(4-((5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indol-1-yl)methyl)phenoxy)acetonitrile→2-(4-((5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indol-1-yl)methyl)phenoxy)acetic acid→1-(azepan-1-yl)-2-(4-((5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indol-1-yl)methyl)phenoxy)ethan-1-one→1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol

Amlodipine Besylate/Bisoprolol FumarateOptimised routesteps: 3total yield: /

4-Hydroxybenzyl alcohol→4-[(2-Isopropoxyethoxy)methyl]phenol→2-(4-{[2-(propan-2-yloxy)ethoxy]methyl}phenoxymethyl)oxirane→(±)-1-[4-[2-(Isopropoxy)ethoxymethyl]phenoxy]-3-(isopropylamino)propan-2-ol→(+/-)-2-(Chloromethyl)oxirane→Propan-2-amine→Isopropylglycol

Amlodipine Besylate/Bisoprolol FumarateOptimised routesteps: 4total yield: /

4-Hydroxybenzaldehyde→4-(Hydroxymethyl)phenol→Ethylene glycol monoisopropyl ether→4-[(2-Isopropoxyethoxy)methyl]phenol→Epichlorohydrin→2-(4-{[2-(propan-2-yloxy)ethoxy]methyl}phenoxymethyl)oxirane→Propan-2-amine

Bazedoxifene AcetateOptimised routesteps: 8total yield: /

Bisoprolol FumarateOptimised routesteps: 3total yield: /

Bisoprolol FumarateOptimised routesteps: 4total yield: /

Intermediates available on this site

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